Evidence map›Paper›PMID 26994633›Full record

ArticleJournal of neuropathology and experimental neurology2016

Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium.

G R Wayne Moore, Cornelia Laule, Esther Leung, Vladimira Pavlova, B Paul Morgan, Margaret M Esiri

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

G R Wayne MooreFrom the Department of Pathology and Laboratory Medicine (GRWM, CL, EL, VP); Department of Radiology, University of British Columbia (CL); Vancouver General Hospital, Vancouver Coastal Health Authority (GRWM); International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre (GRWM, CL, EL, VP), Vancouver, BC, Canada; Institute of Infection and Immunity, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK (BPM); and Neuropathology Department, University of Oxford, John Radcliffe Hospital, Oxford, UK (MME). wayne.moore@vch.ca.
Cornelia LauleFrom the Department of Pathology and Laboratory Medicine (GRWM, CL, EL, VP); Department of Radiology, University of British Columbia (CL); Vancouver General Hospital, Vancouver Coastal Health Authority (GRWM); International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre (GRWM, CL, EL, VP), Vancouver, BC, Canada; Institute of Infection and Immunity, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK (BPM); and Neuropathology Department, University of Oxford, John Radcliffe Hospital, Oxford, UK (MME).
Esther LeungFrom the Department of Pathology and Laboratory Medicine (GRWM, CL, EL, VP); Department of Radiology, University of British Columbia (CL); Vancouver General Hospital, Vancouver Coastal Health Authority (GRWM); International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre (GRWM, CL, EL, VP), Vancouver, BC, Canada; Institute of Infection and Immunity, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK (BPM); and Neuropathology Department, University of Oxford, John Radcliffe Hospital, Oxford, UK (MME).
Vladimira PavlovaFrom the Department of Pathology and Laboratory Medicine (GRWM, CL, EL, VP); Department of Radiology, University of British Columbia (CL); Vancouver General Hospital, Vancouver Coastal Health Authority (GRWM); International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre (GRWM, CL, EL, VP), Vancouver, BC, Canada; Institute of Infection and Immunity, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK (BPM); and Neuropathology Department, University of Oxford, John Radcliffe Hospital, Oxford, UK (MME).
B Paul MorganFrom the Department of Pathology and Laboratory Medicine (GRWM, CL, EL, VP); Department of Radiology, University of British Columbia (CL); Vancouver General Hospital, Vancouver Coastal Health Authority (GRWM); International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre (GRWM, CL, EL, VP), Vancouver, BC, Canada; Institute of Infection and Immunity, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK (BPM); and Neuropathology Department, University of Oxford, John Radcliffe Hospital, Oxford, UK (MME).
Margaret M EsiriFrom the Department of Pathology and Laboratory Medicine (GRWM, CL, EL, VP); Department of Radiology, University of British Columbia (CL); Vancouver General Hospital, Vancouver Coastal Health Authority (GRWM); International Collaboration on Repair Discoveries (ICORD), Blusson Spinal Cord Centre (GRWM, CL, EL, VP), Vancouver, BC, Canada; Institute of Infection and Immunity, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK (BPM); and Neuropathology Department, University of Oxford, John Radcliffe Hospital, Oxford, UK (MME).
Cardiff University · GBInternational Collaboration On Repair Discoveries · CAUniversity of British Columbia · CAVancouver Coastal Health · CAVancouver General Hospital · CA

Funding

Medical Research Council MR/L022656/1
6 · The paper itself

Abstract

The choroid plexus (CP) provides a barrier to entry of toxic molecules from the blood into the brain and transports vital molecules into the cerebrospinal fluid. While a great deal is known about CP physiology, relatively little is known about its immunology. Here, we show immunohistochemical data that help define the role of the CP in innate and adaptive humoral immunity. The results show that complement, in the form of C1q, C3d, C9, or C9neo, is preferentially deposited in stromal concretions. In contrast, immunoglobulin (Ig) G (IgG) and IgA are more often found in CP epithelial cells, and IgM is found in either locale. C4d, IgD, and IgE are rarely, if ever, seen in the CP. In multiple sclerosis CP, basement membrane C9 or stromal IgA patterns were common but were not specific for the disease. These findings indicate that the CP may orchestrate the clearance of complement, particularly by deposition in its concretions, IgA and IgG preferentially via its epithelium, and IgM by either mechanism.

Indexed as

Adaptive ImmunityAdolescentAdultAgedAged, 80 and overBasement MembraneChoroid PlexusComplement System ProteinsEpitheliumFemaleHumansImmunity, HumoralMaleMiddle AgedStromal CellsYoung AdultComplement System ProteinsCerebrospinal fluidChoroid plexusComplementConcretionsImmunoglobulinsImmunologyMultiple sclerosis.

Identifiers

PMID26994633
PMCPMC4824036
OpenAlexW2321214963

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.