Evidence map›Paper›PMID 26994590›Full record

ArticleChembiochem : a European journal of chemical biology2016

Color-Coded Super-Resolution Small-Molecule Imaging.

Paolo Beuzer, James J La Clair, Hu Cang

Open access · greenAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Paolo BeuzerWaitt Advanced Biophotonics Center, The Salk Institute for Biological Sciences, 10010 N Torrey Pines Road, La Jolla, CA, 92037, USA.
James J La ClairWaitt Advanced Biophotonics Center, The Salk Institute for Biological Sciences, 10010 N Torrey Pines Road, La Jolla, CA, 92037, USA. i@xenobe.org.ORCID 0000-0001-6500-4107
Hu CangWaitt Advanced Biophotonics Center, The Salk Institute for Biological Sciences, 10010 N Torrey Pines Road, La Jolla, CA, 92037, USA. hucang@salk.edu.
Salk Institute for Biological Studies · US

Funding

Ultra Sensitive Single Molecule Spectroscopy With Plasmonic AntennasDP2EB020400 · NIBIB · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI CANG, HU · 2014 to 2014
$2.9M
NIBIB NIH HHS DP2 EB020400
6 · The paper itself

Abstract

Although the development of super-resolution microscopy dates back to 1994, its applications have been primarily focused on visualizing cellular structures and targets, including proteins, DNA and sugars. We now report on a system that allows both monitoring of the localization of exogenous small molecules in live cells at low resolution and subsequent super-resolution imaging by using stochastic optical reconstruction microscopy (STORM) on fixed cells. This represents a powerful new tool to understand the dynamics of subcellular trafficking associated with the mode and mechanism of action of exogenous small molecules.

Indexed as

Microscopy, FluorescenceAntibodies, MonoclonalCarbocyaninesCell Line, TumorColorDNAHumansProteinsSmall Molecule LibrariesAlexa Fluor 647Antibodies, MonoclonalCarbocyaninesDNAProteinsSmall Molecule Librariesdrug discoverymicroscopymode of actionnatural productssuper-resolution imaging

Identifiers

PMID26994590
PMCPMC5291120
OpenAlexW2310575067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.