Evidence map›Paper›PMID 26994436›Full record

ArticleJournal of affective disorders2016

Clinical management following self-harm in a UK-wide primary care cohort.

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Open access · hybridAbstract read
In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Hospital presenting suicidal ideation: A systematic review.Clinical psychology & psychotherapy · 2022
    Pooled it
  2. Pharmacological interventions for self-harm in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
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  15. Reducing risk following self-harm: the need for careful prescribing.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
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  18. Yonder: Self-harm, repeat prescribing, deprescribing, and worry.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Matthew J CarrCentre for Mental Health and Safety, Institute of Brain, Behaviour and Mental Health, University of Manchester, UK. Electronic address: matthew.carr@manchester.ac.uk.
Darren M AshcroftCentre for Pharmacoepidemiology and Drug Safety, Manchester Pharmacy School, University of Manchester, UK; NIHR Greater Manchester Primary Care Patient Safety Translational Research Centre, UK.
Evangelos KontopantelisCentre for Health Informatics, Institute of Population Health, University of Manchester, UK; NIHR School for Primary Care Research, University of Manchester, UK.
David WhileCentre for Mental Health and Safety, Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.
Yvonne AwenatSchool of Psychological Sciences, University of Manchester, UK.
Jayne CooperCentre for Mental Health and Safety, Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.
Carolyn Chew-GrahamResearch Institute of Primary Care and Health Sciences, Keele University, UK.
Nav KapurCentre for Mental Health and Safety, Institute of Brain, Behaviour and Mental Health, University of Manchester, UK; Manchester Mental Health and Social Care Trust, UK.
Roger T WebbCentre for Mental Health and Safety, Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.
University of Manchester · GBCentre for Mental Health · GBKeele University · GBManchester Academic Health Science Centre · GB

Funding

Medical Research Council MC_PC_13042Medical Research Council MR/K006665/1
6 · The paper itself

Abstract

backgroundLittle is known about the clinical management of patients in primary care following self-harm.

methodsA descriptive cohort study using data from 684 UK general practices that contributed to the Clinical Practice Research Datalink (CPRD) during 2001-2013. We identified 49,970 patients with a self-harm episode, 41,500 of whom had one complete year of follow-up.

resultsAmong those with complete follow-up, 26,065 (62.8%, 62.3-63.3) were prescribed psychotropic medication and 6318 (15.2%, 14.9-15.6) were referred to mental health services; 4105 (9.9%, CI 9.6-10.2) were medicated without an antecedent psychiatric diagnosis or referral, and 4,506 (10.9%, CI 10.6-11.2) had a diagnosis but were not subsequently medicated or referred. Patients registered at practices in the most deprived localities were 27.1% (CI 21.5-32.2) less likely to be referred than those in the least deprived. Despite a specifically flagged NICE 'Do not do' recommendation in 2011 against prescribing tricyclic antidepressants following self-harm because of their potentially lethal toxicity in overdose, 8.8% (CI 7.8-9.8) of individuals were issued a prescription in the subsequent year. The percentage prescribed Citalopram, an SSRI antidepressant with higher toxicity in overdose, fell sharply during 2012/2013 in the aftermath of a Medicines and Healthcare products Regulatory Agency (MHRA) safety alert issued in 2011.

conclusionsA relatively small percentage of these vulnerable patients are referred to mental health services, and reduced likelihood of referral in more deprived localities reflects a marked health inequality. National clinical guidelines have not yet been effective in reducing rates of tricyclic antidepressant prescribing for this high-risk group.

Indexed as

Healthcare DisparitiesAntidepressive AgentsAntidepressive Agents, TricyclicCitalopramCohort StudiesDrug PrescriptionsFemaleFollow-Up StudiesHumansMaleMiddle AgedPovertyPrimary Health CareReferral and ConsultationSelective Serotonin Reuptake InhibitorsSelf-Injurious BehaviorAntidepressive AgentsAntidepressive Agents, TricyclicCitalopramSelective Serotonin Reuptake InhibitorsDiagnosesMedicationPrimary careReferralsSelf-harm

Identifiers

PMID26994436
PMCPMC4870375
OpenAlexW2296461632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.