ArticleCortex; a journal devoted to the study of the nervous system and behavior2016
Canceled connections: Lesion-derived network mapping helps explain differences in performance on a complex decision-making task.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Activation network mapping for integration of heterogeneous fMRI findings.Nature human behaviour · 2022Pooled it
- Brain network mapping of structural and functional alterations associated with alexithymia.Translational psychiatry · 2026Article
- Brain Structural and Functional Alteration Network Localization of Visual Hallucinations.Schizophrenia bulletin · 2026Article
- Brain network localization of anhedonia.Translational psychiatry · 2026Article
- The Role of the Claustrum in Parkinson's Disease and Vascular Parkinsonism: A Matter of Network?Life (Basel, Switzerland) · 2025Review
- Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia.Schizophrenia bulletin · 2024Article
- Synthetic surprise as the foundation of the psychedelic experience.Neuroscience and biobehavioral reviews · 2024Review
- Lesion network mapping of mania using different normative connectomes.Brain structure & function · 2022Article
- Lesion network mapping predicts post-stroke behavioural deficits and improves localization.Brain : a journal of neurology · 2021Article
- Lesion network mapping: where do we go from here?Brain : a journal of neurology · 2021Article
- Lesion network mapping demonstrates that mind-wandering is associated with the default mode network.Journal of neuroscience research · 2021Article
- Mapping mania symptoms based on focal brain damage.The Journal of clinical investigation · 2020Article
- Functional anomaly mapping reveals local and distant dysfunction caused by brain lesions.NeuroImage · 2020Article
- Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer's disease.Brain : a journal of neurology · 2020Article
- Model-based lesion mapping of cognitive control using the Wisconsin Card Sorting Test.Nature communications · 2019Article
- Lesion network localization of free will.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Examining neural correlates of psychopathology using a lesion-based approach.Neuropsychologia · 2018Article
- Localizing parkinsonism based on focal brain lesions.Brain : a journal of neurology · 2018Article
- Neural signatures of Trail Making Test performance: Evidence from lesion-mapping and neuroimaging studies.Neuropsychologia · 2018Review
- Searching for the neural causes of criminal behavior.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Studies of patients with brain damage have highlighted a broad neural network of limbic and prefrontal areas as important for adaptive decision-making. However, some patients with damage outside these regions have impaired decision-making behavior, and the behavioral impairments observed in these cases are often attributed to the general variability in behavior following brain damage, rather than a deficit in a specific brain-behavior relationship. A novel approach, lesion-derived network mapping, uses healthy subject resting-state functional connectivity (RSFC) data to infer the areas that would be connected with each patient's lesion area in healthy adults. Here, we used this approach to investigate whether there was a systematic pattern of connectivity associated with decision-making performance in patients with focal damage in areas not classically associated with decision-making. These patients were categorized a priori into "impaired" or "unimpaired" groups based on their performance on the Iowa Gambling Task (IGT). Lesion-derived network maps based on the impaired patients showed overlap in somatosensory, motor and insula cortices, to a greater extent than patients who showed unimpaired IGT performance. Akin to the classic concept of "diaschisis" (von Monakow, 1914), this focus on the remote effects that focal damage can have on large-scale distributed brain networks has the potential to inform not only differences in decision-making behavior, but also other cognitive functions or neurological syndromes where a distinct phenotype has eluded neuroanatomical classification and brain-behavior relationships appear highly heterogeneous.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.