SynthesisJournal of the American Heart Association2016
Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts.
Synthesis in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 8 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Effect of off-hours admission on in-hospital mortality in sub-Saharan Africa: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2026Pooled it
- Outcomes following out-of-hours acute appendectomy: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Pooled it
- Weekend admissions and outcomes in patients with pneumonia: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Association Between Out-of-Hour Admission and Short- and Long-Term Mortality in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Magnitude and modifiers of the weekend effect in hospital admissions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- The weekend effect: does hospital mortality differ by day of the week? A systematic review and meta-analysis.BMC health services research · 2018Pooled it
- Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts.Journal of the American Heart Association · 2016Pooled it
- Trial
- Caregiver oral rehydration solution fluid monitoring charts versus standard care for the management of some dehydration among Kenyan children: a randomized controlled trial.International health · 2018Trial
- Timing of emergency department presentation and psychiatric consultation after self-harm or suicide attempts: a registry-based study in Japan.BMC psychiatry · 2026Observational
- Impact of weekend admission on in-hospital mortality in chronic kidney disease: a nationwide analysis of 184 299 hospitalisations in Poland (2017-2021).BMC nephrology · 2026Article
- On Patient Safety: The Weekend Effect.Clinical orthopaedics and related research · 2025Article
- Differences in quality indicators of emergency care between on- and off-hours at Ghanaian district hospitals.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025Article
- Comparing mortality in the elderly after proximal femur fractures and coxarthrosis: the effect of individual health characteristics and day of surgery.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Postoperative Outcomes Following Preweekend Surgery.JAMA network open · 2025Article
- The determinants for death in hospital following moderate to severe traumatic brain injury in Australia.Emergency medicine Australasia : EMA · 2025Article
- Does Timing Matter? The Effect of Intensive Care Unit Arrival Timing on Elective Cardiac Surgery.The Annals of thoracic surgery · 2025Article
- Investigating the "off-hour effect" on outcomes of neonates undergoing emergency gastrointestinal surgery.PeerJ · 2025Article
- Advancements in the Optimization of Surgical Timing in Elderly Patients with Hip Fractures: A Narrative Review and Future Perspectives.Clinical interventions in aging · 2025Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA considerable amount of studies have examined the relationship between off-hours (weekends and nights) admission and mortality risk for various diseases, but the results remain equivocal. METHODS AND
resultsThrough a search of EMBASE, PUBMED, Web of Science, and Cochrane Database of Systematic Reviews, we identified cohort studies that evaluated the association between off-hour admission and mortality risk for disease. In a random effects meta-analysis of 140 identified articles (251 cohorts), off-hour admission was strongly associated with increased mortality for aortic aneurysm (odds ratio, 1.52; 95% CI, 1.30-1.77), breast cancer (1.50, 1.21-1.86), leukemia (1.45, 1.17-1.79), respiratory neoplasm (1.32, 1.20-1.26), pancreatic cancer (1.32, 1.12-1.56), malignant neoplasm of genitourinary organs (1.27, 1.08-1.49), colorectal cancer (1.26, 1.07-1.49), pulmonary embolism (1.20, 1.13-1.28), arrhythmia and cardiac arrest (1.19, 1.09-1.29), and lymphoma (1.19, 1.06-1.34). Weaker (odds ratio <1.19) but statistically significant association was noted for renal failure, traumatic brain injury, heart failure, intracerebral hemorrhage, subarachnoid hemorrhage, stroke, gastrointestinal bleeding, myocardial infarction, chronic obstructive pulmonary disease, and bloodstream infections. No association was found for hip fracture, pneumonia, intestinal obstruction, aspiration pneumonia, peptic ulcer, trauma, diverticulitis, and neonatal mortality. Overall, off-hour admission was associated with increased mortality for 28 diseases combined (odds ratio, 1.11; 95% CI, 1.10-1.13).
conclusionsOff-hour admission is associated with increased mortality risk, and the associations varied substantially for different diseases. Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.