Observational studyJournal of the American Heart Association2016
Relationship Between the Duration of Cardiopulmonary Resuscitation and Favorable Neurological Outcomes After Out-of-Hospital Cardiac Arrest: A Prospective, Nationwide, Population-Based Cohort Study.
Observational study in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Extracorporeal membrane oxygenation for critically ill adults.The Cochrane database of systematic reviews · 2023Pooled it
- Extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis of randomized and propensity score-matched studies.Artificial organs · 2022Pooled it
- Outcomes of in-hospital cardiac arrest in COVID-19 patients: A proportional prevalence meta-analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2022Pooled it
- Full-Scale high-fidelity simulation compared to procedural simulation workshop for veno-arterial ECMO cannulation during refractory cardiac arrest: a randomized controlled trial.BMC medical education · 2026Trial
- Sudden cardiac death in younger adults: a comparative analysis of coronary and non-coronary causes.International journal of cardiology. Heart & vasculature · 2026Article
- In-Hospital Cardiac Resuscitation During Widespread Resident Resignations in South Korea.JAMA network open · 2026Article
- No-Flow Duration and Outcomes After Cardiogenic Out-of-Hospital Cardiac Arrest in Older Adults.JAMA network open · 2026Observational
- Time from Cardiopulmonary Resuscitation Initiation to Prehospital Return of Spontaneous Circulation and Downstream Outcomes Among Adult Out-of-Hospital Cardiac Arrest Patients Achieving Field ROSC: A 2015-2023 Smart Advanced Life Support Registry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Ethics in prehospital extracorporeal cardiopulmonary resuscitation.Resuscitation plus · 2026Article
- Regional cerebral oxygen saturation as an adjunctive tool for termination-of-resuscitation decisions in out-of-hospital cardiac arrest: a prospective observational study.Resuscitation plus · 2026Article
- Time-Dependent Association of Thoracic Anthropometric Parameters with Survival After In-Hospital Cardiac Arrest: A Retrospective Single-Center Observational Study.Journal of clinical medicine · 2026Article
- Development of a national consensus guideline for termination of resuscitation in the out-of-hospital environment.British paramedic journal · 2026Article
- Association Between Illness Severity Scores and Quantitatively Measured Brain Injury in Cardiac Arrest Survivors.Journal of clinical medicine · 2026Article
- Optimal Low-Flow Time of Extracorporeal Cardiopulmonary Resuscitation for Favorable Neurological Outcomes: A Risk-Stratified Approach.Journal of clinical medicine · 2026Article
- Time-critical VA-ECMO-facilitated resuscitation and recovery after acute myocardial infarction with cardiogenic shock and cardiac arrest: a case report.Frontiers in cardiovascular medicine · 2026Article
- Wolf Creek XVIII Part 2: optimizing time intervals in cardiac arrest care.Resuscitation plus · 2026Review
- Cognitive Recovery After Out-of-Hospital Cardiac Arrest: Insights Into Improvement Over 6 Months and the Role of Arrest Duration.Journal of the American Heart Association · 2025Article
- POTEC (Platelet Count, Oxygen Saturation, Time of CPR, Elective Surgery, and Initial ETCOJournal of clinical medicine · 2025Article
- Cardiopulmonary resuscitation duration and patient survival in a South Indian intensive care unit.World journal of critical care medicine · 2025Article
- Duration of resuscitation, regain of consciousness and histopathological severity of hypoxic-ischemic encephalopathy after cardiac arrest.Resuscitation plus · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe determination of appropriate duration of in-the-field cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest (OHCA) patients is one of the biggest challenges for emergency medical service providers and clinicians. The appropriate CPR duration before termination of resuscitation remains unclear and may differ based on initial rhythm. We aimed to determine the relationship between CPR duration and post-OHCA outcomes. METHODS AND
resultsWe analyzed the records of 17 238 OHCA patients (age ≥18 years) who achieved prehospital return of spontaneous circulation. Data were prospectively recorded in a nationwide, Japanese database between 2011 and 2012. The time from CPR initiation to prehospital return of spontaneous circulation (CPR duration) was calculated. The primary end point was 1-month survival with favorable neurological outcomes (Cerebral Performance Category [CPC] scale; CPC 1-2). The 1-month CPC 1-2 rate was 21.8% (n=3771). CPR duration was inversely associated with 1-month CPC 1-2 (adjusted unit odds ratio: 0.95, 95% CI: 0.94-0.95). Among all patients, a cumulative proportion of >99% of 1-month CPC 1-2 was achieved with a CPR duration of 35 minutes. When sorted by the initial rhythm, the CPR duration producing more than 99% of survivors with CPC 1-2 was 35 minutes for shockable rhythms and pulseless electrical activity, and 42 minutes for asystole.
conclusionsCPR duration was independently and inversely associated with favorable 1-month neurological outcomes. The critical prehospital CPR duration for OHCA was 35 minutes in patients with initial shockable rhythms and pulseless electrical activity, and 42 minutes in those with initial asystole.
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Registered trials
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