ArticleJournal of the American Heart Association2016
Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.Circulation · 2026Pooled it
- Association between large artery atherosclerosis and cerebral microbleeds: a systematic review and meta-analysis.Stroke and vascular neurology · 2017Pooled it
- Association Between Carotid Atherosclerosis and Post-Stroke Cognitive Impairment in Patients With Mild Ischemic Stroke: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2026Article
- Is cerebral small vessel disease a central nervous system interstitial fluidopathy?IBRO neuroscience reports · 2024Article
- Malignant solid tumor-related spontaneous intracerebral hemorrhage: a propensity score matching study.PeerJ · 2024Article
- Association of Carotid Intima-Media Thickness with Brain MRI Markers in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Article
- Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study.Journal of Alzheimer's disease : JAD · 2022Article
- Cerebrospinal Fluid CSF Flow Artifacts are Associated with Brain Pulsation in Patients with Severe Carotid Artery Stenoses.Current neurovascular research · 2022Article
- Cerebral small vessel disease combined with cerebral collaterals to predict the prognosis of patients with acute large artery atherosclerotic stroke.Frontiers in neurology · 2022Article
- Carotid intima-media thickness and arterial stiffness in relation to cerebral small vessel disease in neurologically asymptomatic individuals with type 1 diabetes.Acta diabetologica · 2021Article
- Association of Carotid Intima-Media Thickness and Other Carotid Ultrasound Features With Incident Dementia in the ARIC-NCS.Journal of the American Heart Association · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- The Prevalence and Risk Factors of Cerebral Microbleeds: A Community-Based Study in China.Therapeutics and clinical risk management · 2021Article
- Magnetic resonance imaging assessment of cerebral small vessel disease intensification in patients with severe aortic valve stenosis.Polish journal of radiology · 2021Article
- Asymptomatic Carotid Disease and Cognitive Impairment: What Is the Evidence?Frontiers in neurology · 2021Review
- Brain imaging biomarkers of carotid artery disease.Annals of translational medicine · 2020Review
- Premature Parental Cardiovascular Disease and Subclinical Disease Burden in the Offspring.Journal of the American Heart Association · 2020Article
- Association Between Non-high-density Lipoprotein Cholesterol and 3-Month Prognosis in Patients With Spontaneous Intracerebral Hemorrhage.Frontiers in neurology · 2020Article
- Cerebral small vessel disease: neuroimaging markers and clinical implication.Journal of neurology · 2019Review
- Lipid levels and the risk of hemorrhagic stroke among women.Neurology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCarotid atherosclerosis is associated with subclinical ischemic cerebrovascular disease, but its role in hemorrhage-prone small vessel disease-represented by cerebral microbleed (CMB)-is unclear, although vascular risk factors underlie both conditions. We hypothesized that persons with carotid atherosclerosis would have higher risk of CMB, particularly in deep regions. METHODS AND
resultsWe studied 1243 participants in the Framingham Offspring Study (aged 56.9±8.8 years; 53% women) with carotid ultrasound available on 2 occasions (1995-1998 and 2005-2008) prior to brain magnetic resonance imaging. Using multivariable logistic regression, we related baseline carotid stenosis, baseline intima-media thickness, and site-specific carotid intima-media thickness progression (at internal and common carotid locations) to the prevalence and location (lobar or deep plus mixed) of CMB. In addition, we assessed effect modification by lipid levels and use of statin and antithrombotic medications. Carotid stenosis ≥25% (a marker of cerebrovascular atherosclerosis) was associated with presence of CMB overall (Odds Ratio 2.20, 95% CI 1.10-4.40) and at deep and mixed locations (odds ratio 3.60, 95% CI 1.23-10.5). Baseline carotid intima-media thickness was not associated with CMB. Progression of common carotid artery intima-media thickness among persons on hypertension treatment was associated with lower risk of deep and mixed CMB (odds ratio per SD 0.41, 95% CI 0.18-0.96).
conclusionsCumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima-media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may have potential implications for assessment of preventive and therapeutic interventions for subclinical cerebral hemorrhage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.