ArticleApplied and environmental microbiology2016
Wolbachia Modulates Lipid Metabolism in Aedes albopictus Mosquito Cells.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed, 123 citations in OpenAlex.
- Silencing LsAtg8 reduces female fecundity and elevates Wolbachia density in embryos of the rice planthopper Laodelphax striatellus.Pest management science · 2026Article
- Remodeling of host lipid metabolism by Wolbachia strain wAlbB is associated with lipid accumulation and cardiolipin dysregulation in the Aedes aegypti fat body.Parasites & vectors · 2026Article
- Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti.PLoS neglected tropical diseases · 2026Article
- The inhibition mechanism ofFrontiers in microbiology · 2026Review
- Insect Lipid Metabolism in the Presence of Symbiotic and Pathogenic Viruses and Bacteria.Advances in experimental medicine and biology · 2026Review
- Larval diet-mediated morphological trait andFrontiers in insect science · 2026Article
- Dengue virus infection in children: Serum lipidomics profiling for biomarker discovery.PLoS neglected tropical diseases · 2025Article
- Generation of Monoclonal Cultures from Wolbachia-infected Drosophila melanogaster JW18 Cell Line.Journal of visualized experiments : JoVE · 2025Article
- Review
- Wolbachia elevates host methyltransferase expression and alters the mBMC microbiology · 2025Article
- Article
- Role of Vigilin and RACK1 in dengue virus-mSphere · 2025Article
- Potential effect ofFrontiers in microbiology · 2025Article
- Understanding the role of trehalose in interactions betweenFrontiers in cellular and infection microbiology · 2025Review
- Symbiotic Bacteria: Wolbachia, Midgut Microbiota in Mosquitoes and Their Importance for Vector Prevention Strategies.Microbial ecology · 2024Review
- Wolbachia modify host cell metabolite profiles in response to short-term temperature stress.Environmental microbiology reports · 2024Article
- AntiviralmBio · 2024Article
- A comprehensive review ofFrontiers in immunology · 2024Review
- Article
- Impact of the microbiome on mosquito-borne diseases.Protein & cell · 2023Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledCertain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue virus (DENV) by Aedes mosquitoes, and the mechanisms responsible are still not well understood. Direct infusion and liquid chromatography-Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry-based lipidomics analyses were conducted using Aedes albopictus Aa23 cells that were infected with the wMel and wMelPop strains of Wolbachia in comparison to uninfected Aa23-T cells. Substantial shifts in the cellular lipid profile were apparent in the presence of Wolbachia Most significantly, almost all sphingolipid classes were depleted, and some reductions in diacylglycerols and phosphatidylcholines were also observed. These lipid classes have previously been shown to be selectively enriched in DENV-infected mosquito cells, suggesting that Wolbachia may produce a cellular lipid environment that is antagonistic to viral replication. The data improve our understanding of the intracellular interactions between Wolbachia and mosquitoes. IMPORTANCE: Mosquitoes transmit a variety of important viruses to humans, such as dengue virus and Zika virus. Certain strains of the intracellular bacterial genus called Wolbachia found in or introduced into mosquitoes can block the transmission of viruses, including dengue virus, but the mechanisms responsible are not well understood. We found substantial shifts in the cellular lipid profiles in the presence of these bacteria. Some lipid classes previously shown to be enriched in dengue virus-infected mosquito cells were depleted in the presence of Wolbachia, suggesting that Wolbachia may produce a cellular lipid environment that inhibits mosquito-borne viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.