ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Cerebral haemodynamics during experimental intracranial hypertension.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Neonatal cerebral hemodynamics under elevated intracranial pressure: a near-infrared spectroscopy study in piglets.Pediatric research · 2026Article
- A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography.Fluids and barriers of the CNS · 2025Article
- Evaluation of Cardiac Function in Patients with Supratentorial Tumors and Raised Intracranial Pressure: HABIT-ICP, a Prospective Observational Study Using Transthoracic Echocardiography.Asian journal of neurosurgery · 2024Article
- Three-dimensional pseudocontinuous arterial spin labeling with dual postlabeling delay for reflecting cerebral blood flow regulation in patients with hydrocephalus: a retrospective cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Secondary insults prevalence, co-occurrence and relationship with outcome after severe TBI.Brain & spine · 2024Article
- Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Autonomic Nervous System Activity during Refractory Rise in Intracranial Pressure.Journal of neurotrauma · 2021Article
- CSF Dynamics for Shunt Prognostication and Revision in Normal Pressure Hydrocephalus.Journal of clinical medicine · 2021Review
- The Limited Impact of Current Therapeutic Interventions on Cerebrovascular Reactivity in Traumatic Brain Injury: A Narrative Overview.Neurocritical care · 2021Review
- Observations on the Cerebral Effects of Refractory Intracranial Hypertension After Severe Traumatic Brain Injury.Neurocritical care · 2020Article
- Cerebral Blood Flow in Low Intracranial Pressure Headaches-What is Known?Brain sciences · 2019Article
- Use of a Doppler-Based Pulsatility Index to Evaluate Cerebral Hemodynamics in Neurocritical Patients After Hemicraniectomy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019Article
- Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits.Experimental and therapeutic medicine · 2019Article
- Noninvasive ICP Monitoring by Serial Transcranial Doppler in Coagulopathic Patient.Neurocritical care · 2019Article
- Impaired cerebral compensatory reserve is associated with admission imaging characteristics of diffuse insult in traumatic brain injury.Acta neurochirurgica · 2018Article
- Validation of Pressure Reactivity and Pulse Amplitude Indices against the Lower Limit of Autoregulation, Part I: Experimental Intracranial Hypertension.Journal of neurotrauma · 2018Article
- Compensatory-Reserve-Weighted Intracranial Pressure and Its Association with Outcome After Traumatic Brain Injury.Neurocritical care · 2018Article
- Intracranial Pressure Is a Determinant of Sympathetic Activity.Frontiers in physiology · 2018Article
- Relationship Between Brain Pulsatility and Cerebral Perfusion Pressure: Replicated Validation Using Different Drivers of CPP Change.Neurocritical care · 2017Article
- Individualizing Thresholds of Cerebral Perfusion Pressure Using Estimated Limits of Autoregulation.Critical care medicine · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
Intracranial hypertension is a common final pathway in many acute neurological conditions. However, the cerebral haemodynamic response to acute intracranial hypertension is poorly understood. We assessed cerebral haemodynamics (arterial blood pressure, intracranial pressure, laser Doppler flowmetry, basilar artery Doppler flow velocity, and vascular wall tension) in 27 basilar artery-dependent rabbits during experimental (artificial CSF infusion) intracranial hypertension. From baseline (∼9 mmHg; SE 1.5) to moderate intracranial pressure (∼41 mmHg; SE 2.2), mean flow velocity remained unchanged (47 to 45 cm/s; p = 0.38), arterial blood pressure increased (88.8 to 94.2 mmHg; p < 0.01), whereas laser Doppler flowmetry and wall tension decreased (laser Doppler flowmetry 100 to 39.1% p < 0.001; wall tension 19.3 to 9.8 mmHg, p < 0.001). From moderate to high intracranial pressure (∼75 mmHg; SE 3.7), both mean flow velocity and laser Doppler flowmetry decreased (45 to 31.3 cm/s p < 0.001, laser Doppler flowmetry 39.1 to 13.3%, p < 0.001), arterial blood pressure increased still further (94.2 to 114.5 mmHg; p < 0.001), while wall tension was unchanged (9.7 to 9.6 mmHg; p = 0.35).This animal model of acute intracranial hypertension demonstrated two intracranial pressure-dependent cerebroprotective mechanisms: with moderate increases in intracranial pressure, wall tension decreased, and arterial blood pressure increased, while with severe increases in intracranial pressure, an arterial blood pressure increase predominated. Clinical monitoring of such phenomena could help individualise the management of neurocritical patients.
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