ArticleThe European physical journal. E, Soft matter2016
Internal tension in a collapsed polymer under shear flow and the connection to enzymatic cleavage of von Willebrand factor.
Article in The European physical journal. E, Soft matter, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mechanical forces control the valency of the malaria adhesin VAR2CSA by exposing cryptic glycan binding sites.PLoS computational biology · 2023Article
- Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging.Blood · 2022Article
- Exposure of Von Willebrand Factor Cleavage Site in A1A2A3-Fragment under Extreme Hydrodynamic Shear.Polymers · 2021Article
- Predicting pathological von Willebrand factor unraveling in elongational flow.Biophysical journal · 2021Article
- Prediction of Sub-Monomer A2 Domain Dynamics of the von Willebrand Factor by Machine Learning Algorithm and Coarse-Grained Molecular Dynamics Simulation.Scientific reports · 2019Article
- Shear-Induced Extensional Response Behaviors of Tethered von Willebrand Factor.Biophysical journal · 2019Article
- Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow.Biophysical journal · 2018Article
- Article
- Coarse-Grain Modeling of Shear-Induced Binding between von Willebrand Factor and Collagen.Biophysical journal · 2018Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By means of Brownian hydrodynamics simulations we show that the tension distribution along the contour of a single collapsed polymer in shear flow is inhomogeneous and above a threshold shear rate exhibits a double-peak structure when hydrodynamic interactions are taken into account. We argue that the tension maxima close to the termini of the polymer chain reflect the presence of polymeric protrusions. We establish the connection to shear-induced globule unfolding and determine the scaling behavior of the maximal tensile forces and the average protrusion length as a function of shear rate, globule size, and cohesive strength. A quasi-equilibrium theory is employed in order to describe the simulation results. Our results are used to explain experimental data for the shear-sensitive enzymatic degradation of von Willebrand factor.
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Registered trials
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