ArticleThe journal of pain2016
Reduced Modulation of Pain in Older Adults After Isometric and Aerobic Exercise.
Article in The journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Understanding Exercise-Induced Hypoalgesia: An Umbrella Review of Scientific Evidence and Qualitative Content Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Comparative effectiveness of exercise interventions for primary dysmenorrhea: a systematic review and network meta-analysis.BMC women's health · 2024Pooled it
- Evidence synthesis of types and intensity of therapeutic land-based exercises to reduce pain in individuals with knee osteoarthritis.Rheumatology international · 2019Pooled it
- Comparison of anti-gravity treadmill training and traditional treadmill training in patients with moderate to severe knee osteoarthritis: A randomized controlled trial.Irish journal of medical science · 2025Trial
- Peer-Delivered Cognitive Behavioral Training to Improve Functioning in Patients With Diabetes: A Cluster-Randomized Trial.Annals of family medicine · 2020Trial
- Exploring real-world acute associations between physical activity and bodily pain in middle-aged and older adults.Pain reports · 2026Article
- Pre-Exercise Factors Associated with the Magnitude of Exercise-Induced Hypoalgesia in Individuals with Knee Osteoarthritis: A Cross-Sectional, Observational Study.Journal of clinical medicine · 2025Article
- Do Physical Activities Prevent the Occurrence of Bothersome Pain?Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Impact of electrical muscle stimulation-induced muscle contractions on endogenous pain modulatory system: a quantitative sensory testing evaluation.BMC musculoskeletal disorders · 2024Article
- Conservative Management of Occipital Neuralgia Supported by Physical Therapy: A Review of Available Research and Mechanistic Rationale to Guide Treatment.Current pain and headache reports · 2024Review
- Opposite effects of isometric exercise on pain sensitivity of healthy individuals: the role of pain modulation.Pain reports · 2024Article
- The effect of resistance exercise on multimodal pain thresholds in local and systemic muscle sites.Physiological reports · 2024Article
- Age- and Sex-Dependent Effects of Moderate Exercise on Endogenous Pain Inhibition in Rats.Biomedicines · 2024Article
- Exercise-induced hypoalgesia in chronic neck pain: A narrative review.Sports medicine and health science · 2024Review
- Examining Changes in Pain Sensitivity Following 8 Minutes of Cycling at Varying Exercise Intensities.International journal of exercise science · 2024Article
- The sodium does not affect joint pain and functional activity of knee osteoarthritis patients.Journal of public health in Africa · 2023Article
- Longitudinal relationships between habitual physical activity and pain tolerance in the general population.PloS one · 2023Article
- The Interaction Between Psychosocial Factors and Exercise-Induced Hypoalgesia in Pain-Free Nurses.Journal of pain research · 2023Article
- Lean Mass is Associated with, but Does Not Mediate Sex Differences in Pressure Pain Sensitivity in Healthy Adults.Journal of pain research · 2022Article
- Effects of Exercise-Induced Hypoalgesia at Different Aerobic Exercise Intensities in Healthy Young Adults.Journal of pain research · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledLaboratory-based studies show that acute aerobic and isometric exercise reduces sensitivity to painful stimuli in young healthy individuals, indicative of a hypoalgesic response. However, little is known regarding the effect of aging on exercise-induced hypoalgesia (EIH). The purpose of this study was to examine age differences in EIH after submaximal isometric exercise and moderate and vigorous aerobic exercise. Healthy older and younger adults completed 1 training session and 4 testing sessions consisting of a submaximal isometric handgrip exercise, vigorous or moderate intensity stationary cycling, or quiet rest (control). The following measures were taken before and after exercise/quiet rest: 1) pressure pain thresholds, 2) suprathreshold pressure pain ratings, 3) pain ratings during 30 seconds of prolonged noxious heat stimulation, and 4) temporal summation of heat pain. The results revealed age differences in EIH after isometric and aerobic exercise, with younger adults experiencing greater EIH compared with older adults. The age differences in EIH varied across pain induction techniques and exercise type. These results provide evidence for abnormal pain modulation after acute exercise in older adults. PERSPECTIVE: This article enhances our understanding of the influence of a single bout of exercise on pain sensitivity and perception in healthy older compared with younger adults. This knowledge could help clinicians optimize exercise as a method of pain management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.