SynthesisDigestive diseases and sciences2016
Significant Association Between Gallstone Disease and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Synthesis in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease.Frontiers in endocrinology · 2022Pooled it
- Genome-wide analyses identify 60 loci associated with liver triglyceride content.Nature genetics · 2026Article
- Prevalence and metabolic correlates of gallbladder stones among community-dwelling older adults in Chongqing, China: a repeated cross-sectional study, 2018-2025.BMC gastroenterology · 2026Article
- Effect of cholecystectomy on liver fat and fibrosis in metabolic dysfunction-associated steatotic liver disease patients.World journal of gastrointestinal pharmacology and therapeutics · 2026Article
- Triglyceride-glucose body mass index and metabolic dysfunction-associated steatotic liver disease in hospitalized patients with type 2 diabetes: a sex-stratified cross-sectional study.BMC endocrine disorders · 2026Article
- Article
- Gallstone disease as a clue for metabolic syndrome.Caspian journal of internal medicine · 2026Article
- Association between cholecystectomy and the risk of new-onset metabolic dysfunction-associated steatotic liver disease: a risk-stratified cohort study.Scientific reports · 2025Article
- Metabolic abnormalities, liver enzymes increased risk of gallstones: a cross-sectional study and multivariate mendelian randomization analysis.Internal and emergency medicine · 2025Article
- Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults.Frontiers in medicine · 2025Article
- Gallstones increase the risk of nonalcoholic fatty liver: A case-control study.Health science reports · 2024Article
- Liver biopsy in patients with gall stone disease and concomitant non-alcoholic fatty liver disease undergoing cholecystectomy: A prospective observational study.Turkish journal of surgery · 2024Article
- Causal effects from nonalcoholic fatty liver disease on cholelithiasis: A mendelian randomization study.Health science reports · 2024Article
- Review
- Article
- Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice.International journal of molecular sciences · 2022Article
- Cholecystectomy reduces the risk of myocardial and cerebral infarction in patients with gallstone-related infection.Scientific reports · 2022Article
- Causal associations between changes in lipid profiles and risk of gallstone disease: a two-sample Mendelian randomization study.Annals of translational medicine · 2022Article
- Factors Influencing Gallstone Formation: A Review of the Literature.Biomolecules · 2022Review
- Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study.BMC endocrine disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGallstone disease (GD) and nonalcoholic fatty liver disease (NAFLD) are common digestive disorders worldwide. Both conditions share certain risk factors including obesity, insulin resistance and diabetes. Several epidemiologic studies have reported the relationship between these two conditions.
aimWe conducted a systematic review and meta-analysis to characterize the association between GD and NAFLD.
methodsA comprehensive search of the databases MEDLINE and EMBASE was performed from inception through November 2015. The inclusion criterion was the observational studies' assessment of the association between GD and NAFLD in adult participants. Pooled odds ratio (OR) and 95 % confidence interval (CI) were calculated using a random-effects model.
resultsData were extracted from 12 observational studies (9 cross-sectional studies, 1 case-control study and 2 cohort studies). The pooled OR of NAFLD in patients who had GD was 1.55 (95 % CI 1.31-1.82). The statistical between-studies heterogeneity (I (2)) was 64 %. The association remained significant when limited to cohort studies with pooled OR 1.33 (95 % CI 1.14-1.55, I (2) = 0 %).
conclusionOur meta-analysis demonstrated that GD is significantly associated with NAFLD. Further prospective studies exploring the underlying mechanism of this association should be pursued.
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