Evidence map›Paper›PMID 26993627›Full record

ReviewCurrent HIV/AIDS reports2016

PrEP as Peri-conception HIV Prevention for Women and Men.

Renee Heffron, Jillian Pintye, Lynn T Matthews, Shannon Weber, Nelly Mugo

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03030768 (Pilot of an mHealth-enhanced, Safer Conception Intervention to Reduce HIV-1 Risk Among Kenyan HIV-1 Serodiscordant Couples), which is not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03030768 completednot on this map

Pilot of an mHealth-enhanced, Safer Conception Intervention to Reduce HIV-1 Risk Among Kenyan HIV-1 Serodiscordant Couples

TypeobservationalSponsorUniversity of WashingtonRan2016 to 2018Enrolled74ConditionsHIV Seropositivity, Pregnancy, High-RiskArmsPrEP, Counseling on timed condomless sex, ART and PrEP adherence
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
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  17. Review
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  19. A clinical practice guide: What HIV care providers need to know about HIV pregnancy planning to optimize preconception care for their patients.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Renee HeffronDepartments of Global Health and Epidemiology, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA. rheffron@uw.edu.
Jillian PintyeSchool of Nursing, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA, 98104, USA.
Lynn T MatthewsDivision of Infectious Disease and Center for Global Health, Massachusetts General Hospital, 125 Nashua Street, Suite 722, Boston, MA, 02114, USA.
Shannon WeberUniversity of California San Francisco, 1001 Potrero Ave, 6D-33, San Francisco, CA, 94110, USA.
Nelly MugoCenter for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya.
University of Washington · USKenya Medical Research Institute · KEMassachusetts General Hospital · USUniversity of California, San Francisco · US

Funding

Periconception HIV risk reduction for HIV-discordant couples in UgandaK23MH095655 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MATTHEWS, LYNN T · 2011 to 2015
$854k
Antiretroviral periconception HIV prevention for HIV discordant couplesR00HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2015 to 2017
$742k
Antiretroviral periconception HIV prevention for HIV discordant couplesK99HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2013 to 2014
$208k
NICHD NIH HHS K99 HD076679NICHD NIH HHS R00 HD076679NIMH NIH HHS K23 MH095655
6 · The paper itself

Abstract

Daily oral tenofovir (TDF)-based pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy and recommended for men and women with substantial risk of HIV acquisition. The peri-conception period, the stage prior to pregnancy when condom use is necessarily reduced, has elevated HIV risk that can be mitigated by PrEP use. Data from a randomized trial suggest that peri-conception PrEP use by HIV-seronegative women does not increase the risk of pregnancy loss, birth defects or congenital anomalies, preterm birth, or infant growth faltering. Women considering PrEP use throughout pregnancy must weigh the known increased risk of HIV acquisition with unknown risks of drug effects on infant growth. PrEP has been used safely by HIV-seronegative men with HIV-seropositive female partners who have become pregnant. As an effective user-controlled HIV prevention strategy, PrEP offers autonomy and empowerment for HIV prevention and can be recommended alongside antiretroviral therapy, fertility screening, vaginal self-insemination, intercourse timed to peak fertility, medically assisted reproduction, and other safer conception strategies to provide multiple options. The integration of PrEP into safer conception programs is warranted and will safely reduce HIV transmission to women, men, and children during the peri-conception period.

Indexed as

Pre-Exposure ProphylaxisPrenatal CareAnti-HIV AgentsFemaleHIV InfectionsHumansKenyaMaleMedication AdherencePregnancyPregnancy Complications, InfectiousRandomized Controlled Trials as TopicTenofovirUgandaAnti-HIV AgentsTenofovirHIV preventionPeri-conceptionPre-exposure prophylaxisPregnancyPrEPReviewSafer conceptionScience of prevention

Identifiers

PMID26993627
PMCPMC4891263
OpenAlexW2303386886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.