Trial reportEuropean journal of nuclear medicine and molecular imaging2016
Human brown adipose tissue [(15)O]O2 PET imaging in the presence and absence of cold stimulus.
Trial report in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review.Frontiers in endocrinology · 2022Pooled it
- Infrared Thermography for Estimating Supraclavicular Skin Temperature and BAT Activity in Humans: A Systematic Review.Obesity (Silver Spring, Md.) · 2019Pooled it
- Effects of Whole-Body Cryotherapy Combined With Conventional Obesity Management Versus Obesity Management Alone: A Clinical Trial.Obesity (Silver Spring, Md.) · 2025Trial
- No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial.Nature communications · 2022Trial
- Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females.The Journal of clinical endocrinology and metabolism · 2022Trial
- Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function.American journal of physiology. Endocrinology and metabolism · 2022Trial
- Cissus Quadrangularis enhances UCP1 mRNA, indicative of white adipocyte browning and decreases central obesity in humans in a randomized trial.Scientific reports · 2021Trial
- Near-Infrared Spatially Resolved Spectroscopy as an Indirect Technique to Assess Brown Adipose Tissue in Young Women.Molecular imaging and biology · 2019Trial
- Regulation of human brown adipose tissue by adenosine and AEuropean journal of nuclear medicine and molecular imaging · 2019Trial
- Human brown fat metabolism associates with systemic branched-chain amino acids homeostasis.Molecular metabolism · 2026Article
- Maintenance of core temperature in SCUBA divers in cold water: contributions of anthropometrics, suit type, and sex.European journal of applied physiology · 2026Article
- Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ.Molecular metabolism · 2026Article
- Shiny-Calorie: a context-aware application for indirect calorimetry data analysis and visualization using R.Bioinformatics advances · 2026Article
- Recent updates on cold adaptation in population and laboratory studies, including cross-adaptation with nonthermal factors.Journal of physiological anthropology · 2025Review
- Cold exposure and thermoneutrality similarly reduce supraclavicular brown adipose tissue fat fraction in fasted young lean adults.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Energy expenditure during physical work in cold environments: physiology and performance considerations for military service members.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- Highland deer mice support increased thermogenesis in response to chronic cold hypoxia by shifting uptake of circulating fatty acids from muscles to brown adipose tissue.The Journal of experimental biology · 2024Article
- Indication of mixed glucose and fatty acid use by inferred brown adipose tissue activity in Samoans.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Metabolic Effects of Brown Adipose Tissue Activity Due to Cold Exposure in Humans: A Systematic Review and Meta-Analysis of RCTs and Non-RCTs.Biomedicines · 2024Review
- Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBrown adipose tissue (BAT) is considered a potential target for combatting obesity, as it produces heat instead of ATP in cellular respiration due to uncoupling protein-1 (UCP-1) in mitochondria. However, BAT-specific thermogenic capacity, in comparison to whole-body thermogenesis during cold stimulus, is still controversial. In our present study, we aimed to determine human BAT oxygen consumption with [(15)O]O2 positron emission tomography (PET) imaging. Further, we explored whether BAT-specific energy expenditure (EE) is associated with BAT blood flow, non-esterified fatty acid (NEFA) uptake, and whole-body EE.
methodsSeven healthy study subjects were studied at two different scanning sessions, 1) at room temperature (RT) and 2) with acute cold exposure. Radiotracers [(15)O]O2, [(15)O]H2O, and [(18)F]FTHA were given for the measurements of BAT oxygen consumption, blood flow, and NEFA uptake, respectively, with PET-CT. Indirect calorimetry was performed to assess differences in whole-body EE between RT and cold.
resultsBAT-specific EE and oxygen consumption was higher during cold stimulus (approx. 50 %); similarly, whole-body EE was higher during cold stimulus (range 2-47 %). However, there was no association in BAT-specific EE and whole-body EE. BAT-specific EE was found to be a minor contributor in cold induced whole-body thermogenesis (almost 1 % of total whole-body elevation in EE). Certain deep muscles in the cervico-thoracic region made a major contribution to this cold-induced thermogenesis (CIT) without any visual signs or individual perception of shivering. Moreover, BAT-specific EE associated with BAT blood flow and NEFA uptake both at RT and during cold stimulus.
conclusionOur study suggests that BAT is a minor and deep muscles are a major contributor to CIT. In BAT, both in RT and during cold, cellular respiration is linked with circulatory NEFA uptake.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.