ArticleEuropean journal of nuclear medicine and molecular imaging2016
Segmental quantitative myocardial perfusion with PET for the detection of significant coronary artery disease in patients with stable angina.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04973410 (FLOW 3 - The Association Between Catheter-based Coronary Flow and Resistance and 15O-H2O Positron Emission Tomography Scan-based Absolute Myocardial Blood Flow in the Coronary Artery Territory.), which is not on this map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FLOW 3 - The Association Between Catheter-based Coronary Flow and Resistance and 15O-H2O Positron Emission Tomography Scan-based Absolute Myocardial Blood Flow in the Coronary Artery Territory.
Who cites it
12 citing papers in PubMed.
- 18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease categorization.European heart journal. Cardiovascular Imaging · 2022Trial
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Myocardial perfusion quantification with Rb-82 PET: good interobserver agreement of Carimas software on global, regional, and segmental levels.Annals of nuclear medicine · 2022Article
- Evaluation of quantitative CMR perfusion imaging by comparison with simultaneousJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Sub-endocardial and sub-epicardial measurement of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Observational
- Emerging F-18-Labelled PET Myocardial Perfusion Tracers.Current cardiology reports · 2020Review
- Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Multimodality quantitative assessments of myocardial perfusion using dynamic contrast enhanced magnetic resonance andIEEE transactions on radiation and plasma medical sciences · 2018Article
- Topics of nuclear medicine research in Europe.Annals of nuclear medicine · 2017Review
- Recent Progress in PET and SPECT Myocardial Perfusion Imaging: From Radiopharmaceuticals to Imaging Innovations.Iranian journal of pharmaceutical research : IJPRReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe goal of this study is to determine the technical accuracy of segmental perfusion parameters assessed with quantitative cardiac PET imaging in the evaluation of coronary artery disease (CAD) in patients with stable angina.
methodsA cohort of patients who participated in the EVINCI protocol underwent an evaluation of coronary anatomy by invasive coronary angiography (ICA) and/or coronary computed tomography angiography (CCTA) and PET myocardial perfusion imaging with H2 (15)O, (13)NH3 or (82)Rb. PET studies were analyzed by two independent observers blinded to clinical and instrumental data, and classified as positive or negative for significant CAD using only segmental perfusion measurements and cut-off values from literature.
resultsOn a per-patient basis, the overall inter-observer agreement on PET results was 90 % (kappa = 0.79), indicating substantial agreement. On a per-vessel basis, the inter-observer agreement on PET results was 88 % (kappa = 0.74) in the RCA territory, 94 % (kappa = 0.84) in the LAD territory and 94 % (kappa = 0.85) in the LCX territory. Segmental PET measurements correctly identified 85 % of the patients, resulting in a global sensitivity of 86 %, a specificity of 84 %, a positive predictive value (PPV) of 69 % and a negative predictive value (NPV) of 93 %. In vessel-based analyses, quantitative perfusion parameters had a sensitivity, specificity, PPV and NPV of 92 %, 82 %, 42 % and 99 %, respectively, for the detection of significant coronary stenoses in all major coronary arteries.
conclusionsThe assessment of absolute myocardial perfusion parameters measured at a segment level lead to reliable and accurate identification of patients with significant coronary stenosis at ICA and/or CCTA.
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