Evidence map›Paper›PMID 26993214›Full record

ArticleJournal of neurotrauma2017

Diffusion-Derived Magnetic Resonance Imaging Measures of Longitudinal Microstructural Remodeling Induced by Marrow Stromal Cell Therapy after Traumatic Brain Injury.

Lian Li, Michael Chopp, Guangliang Ding, Changsheng Qu, Siamak P Nejad-Davarani, Esmaeil Davoodi-Bojd, Qingjiang Li, Asim Mahmood, Quan Jiang

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lian Li1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Michael Chopp1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Guangliang Ding1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Changsheng Qu3 Department of Neurosurgery, Henry Ford Hospital , Detroit, Michigan.
Siamak P Nejad-Davarani1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Esmaeil Davoodi-Bojd1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Qingjiang Li1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Asim Mahmood3 Department of Neurosurgery, Henry Ford Hospital , Detroit, Michigan.
Quan Jiang1 Department of Neurology, Henry Ford Hospital , Detroit, Michigan.
Henry Ford Hospital · US

Funding

Ac-SDKP for Treatment of Acute StrokeR01NS079612 · NINDS · HENRY FORD HEALTH SYSTEM · PI ZHANG, ZHENG GANG · 2013 to 2017
$1.6M
MSCs Induce Brain Plasticity via tPAR01AG037506 · NIA · HENRY FORD HEALTH SYSTEM · PI CHOPP, MICHAEL · 2011 to 2015
$1.5M
Treatment of stroke with a clinically approved proteasome inhibitorR01NS062832 · NINDS · HENRY FORD HEALTH SYSTEM · PI ZHANG, LI · 2008 to 2012
$1.4M
Imaging Cell Based Treatment of Traumatic Brain InjuryR01NS064134 · NINDS · HENRY FORD HEALTH SYSTEM · PI JIANG, QUAN · 2011 to 2014
$1.3M
Impairment of the glymphatic system in the aged diabetic brainR21AG052735 · NIA · HENRY FORD HEALTH SYSTEM · PI JIANG, QUAN, ZHANG, LI · 2016 to 2017
$412k
NIA NIH HHS R01 AG037506NIA NIH HHS R21 AG052735NINDS NIH HHS R01 NS062832NINDS NIH HHS R01 NS064134NINDS NIH HHS R01 NS079612
6 · The paper itself

Abstract

Using magnetic resonance imaging (MRI) and an animal model of traumatic brain injury (TBI), we investigated the capacity and sensitivity of diffusion-derived measures, fractional anisotropy (FA), and diffusion entropy, to longitudinally identify structural plasticity in the injured brain in response to the transplantation of human bone marrow stromal cells (hMSCs). Male Wistar rats (300-350g, n = 30) were subjected to controlled cortical impact TBI. At 6 h or 1 week post-injury, these rats were intravenously injected with 1 mL of saline (at 6 h or 1 week, n = 5/group) or with hMSCs in suspension (∼3 × 10

Indexed as

AnimalsBrain Injuries, TraumaticDiffusion Magnetic Resonance ImagingMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRatsRats, Wistardiffusiondiffusion entropyFAMSCswhite matter reorganization

Identifiers

PMID26993214
PMCPMC5198107
OpenAlexW2364531337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.