ArticleDiabetes2016
Differences in In Vivo Cellular Kinetics in Abdominal and Femoral Subcutaneous Adipose Tissue in Women.
Article in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Adipose depot-specific effects of 16 weeks of pioglitazone on in vivo adipogenesis in women with obesity: a randomised controlled trial.Diabetologia · 2021Trial
- The regulation of intrahepatic fatty acid partitioning within the human liver: the effect of sex.Clinical science (London, England : 1979) · 2026Review
- Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health.Nature reviews. Endocrinology · 2025Review
- Deuterated water (Frontiers in immunology · 2025Article
- Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus.Heliyon · 2024Review
- Review
- Measuring In Vivo Adipose Tissue Kinetics in Humans Using the Deuterium (2H)-Labeling Approach.Journal of visualized experiments : JoVE · 2023Article
- The Sexual Dimorphism of Human Adipose Depots.Biomedicines · 2022Review
- Single cell full-length transcriptome of human subcutaneous adipose tissue reveals unique and heterogeneous cell populations.iScience · 2022Article
- Article
- Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.Frontiers in endocrinology · 2022Article
- Article
- CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution.Obesity (Silver Spring, Md.) · 2021Article
- Obesity and endocrine-disrupting chemicals.Endocrine connections · 2021Review
- Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver.Nature reviews. Endocrinology · 2021Review
- Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo.PloS one · 2021Article
- Mouse Abdominal Fat Depots Reduced by Butyric Acid-ProducingMicroorganisms · 2020Article
- Sex Differences in Adipose Tissue Function.Endocrinology and metabolism clinics of North America · 2020Review
- Relationship between epicardial adipose tissue thickness and epicardial adipocyte size with increasing body mass index.Adipocyte · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The accumulation of fat in upper-body (abdominal) adipose tissue is associated with obesity-related cardiometabolic diseases, whereas lower-body (gluteal and femoral) fat may be protective. Studies suggest physiological and molecular differences between adipose depots and depot-specific cellular mechanisms of adipose expansion. We assessed in vivo cellular kinetics in subcutaneous adipose tissue from the abdominal (scABD) and femoral (scFEM) depots using an 8-week incorporation of deuterium ((2)H) from (2)H2O into the DNA of adipocytes and preadipocytes in 25 women with overweight or obesity. DNA synthesis rates denote new cell formation of preadipocytes and adipocytes in each depot. Formation of adipocytes was positively correlated to that of preadipocytes in the scABD and scFEM depots and was related to percent body fat in each depot. Notably, preadipocytes and adipocytes had higher formation rates in the scFEM depot relative to the scABD. This method to assess in vivo adipogenesis will be valuable to evaluate adipocyte kinetics in individuals with varying body fat distributions and degrees of metabolic health and in response to a variety of interventions, such as diet, exercise, or pharmacological treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.