ArticleDiabetes2016
Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study.
Article in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06670625 (Intensive Dietary and Activity Counselling), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intensive Dietary and Activity Counselling
Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Association between family history, early growth and the risk of beta cell autoimmunity in children at risk for type 1 diabetes.Diabetologia · 2021Trial
- Impact of Body Size on Preclinical Type 1 Diabetes Development and Progression.Diabetes care · 2026Review
- A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.Diabetes care · 2026Article
- The Contribution of BMI to a Young Child's Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2.Diabetes care · 2025Article
- Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study.Diabetes care · 2025Review
- Looking back at the TEDDY study: lessons and future directions.Nature reviews. Endocrinology · 2025Review
- Article
- Review
- Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort.Pediatric diabetes · 2023Article
- Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
- Linear Growth and Final Height in People With Type 1 Diabetes: A Study From Karachi, Pakistan.Cureus · 2022Article
- Growth in Children with HLA-Conferred Susceptibility to Type 1 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Multivariate piecewise joint models with random change-points for skewed-longitudinal and survival data.Journal of applied statistics · 2022Article
- Environmental Triggering of Type 1 Diabetes Autoimmunity.Frontiers in endocrinology · 2022Review
- Autoimmune reaction against pancreatic beta cells in children and adolescents with simple obesity.Frontiers in endocrinology · 2022Observational
- Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study.Diabetologia · 2021Article
- The Multifactorial Progression from the Islet Autoimmunity to Type 1 Diabetes in Children.International journal of molecular sciences · 2021Review
- Maternal food consumption during late pregnancy and offspring risk of islet autoimmunity and type 1 diabetes.Diabetologia · 2021Observational
- Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk.Diabetologia · 2021Article
- Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 4 countries.
Funding
Abstract
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P < 0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.