Evidence map›Paper›PMID 26993039›Full record

ArticleNeurogastroenterology and motility2016

Relationships of abdominal pain, reports to visceral and temperature pain sensitivity, conditioned pain modulation, and heart rate variability in irritable bowel syndrome.

M E Jarrett, C J Han, K C Cain, R L Burr, R J Shulman, P G Barney, B D Naliboff, J Zia, M M Heitkemper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

M E JarrettDepartment of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA.
C J HanDepartment of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA.
K C CainDepartment of Biostatistics and Office of Nursing Research, University of Washington, Seattle, WA, USA.
R L BurrDepartment of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA.
R J ShulmanBaylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
P G BarneyDepartment of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA.
B D NaliboffUCLA CNS: Center for Neurovisceral Sciences & Women's Health, UCLA, Los Angeles, CA, USA.
J ZiaDivision of Gastroenterology, School of Medicine, University of Washington Medical Center, Seattle, WA, USA.
M M HeitkemperDepartment of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA.
University of Washington · USNeurobehavioral Systems · USTexas Children's Hospital · USUCLA Health · USUniversity of Washington Medical Center · US

Funding

Partnership CoreP30NR004001 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN · 1994 to 2008
$3.7M
Abdominal Symptom Phenotypes: Pathways to New BiomarkersRC2NR011959 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN, SHULMAN, ROBERT J · 2009 to 2010
$1.9M
NINR NIH HHS P30 NR004001NINR NIH HHS RC2 NR011959
6 · The paper itself

Abstract

backgroundIrritable bowel syndrome (IBS) is a heterogeneous condition with a number of pathophysiological mechanisms that appear to contribute to symptom chronicity. One of these is altered pain sensitivity.

methodsWomen between ages 18-45 were recruited the community. Of those enrolled, 56 had IBS and 36 were healthy control (HC) women. Participants completed questionnaires, kept a 4-week symptom diary and had a 12-h Holter placed to assess nighttime heart rate variability including high frequency power (HF), low frequency power (LF), and total power (TP). At mid-follicular phase approximately 80% of women completed a thermal pain sensitivity test with conditioned pain modulation and visceral pain sensitivity using a water load symptom provocation (WLSP) test. KEY

resultsAs expected, daily abdominal pain was significantly higher in the IBS compared to HC group. There were no differences between the bowel pattern subgroups (IBS-diarrhea [IBS-D], IBS-constipation plus mixed [IBS-CM]). Thermal pain sensitivity did not differ between the IBS and the HC groups, but was significantly higher in the IBS-CM group than the IBS-D group. In the WLSP test, the IBS group experienced significantly more symptom distress than HCs and the IBS-CM group was higher than the IBS-D group. Heart rate variability indicators did not differ between the groups or IBS subgroups. Daily abdominal pain was positively correlated with LF and TP in the IBS group. CONCLUSIONS & INFERENCES: Despite similar levels of abdominal pain in IBS, the IBS-CM group demonstrated greater sensitivity to both thermal and visceral testing procedures.

Indexed as

Abdominal PainAdultFemaleHeart RateHot TemperatureHumansIrritable Bowel SyndromePain MeasurementPain ThresholdVisceral PainYoung Adultautonomic nervous systemconditioned pain modulationheart rate variabilityirritable bowel syndromewater load symptom provocation test

Identifiers

PMID26993039
PMCPMC5283077
OpenAlexW2300734654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.