ArticleCancer medicine2016
Dynamic changes of driver genes' mutations across clinical stages in nine cancer types.
Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Arginines of the CGN codon family are Achilles' heels of cancer genes.Scientific reports · 2024Article
- Translating Molecular Biology Discoveries to Develop Targeted Cancer Interception in Barrett's Esophagus.International journal of molecular sciences · 2023Review
- Highly Sensitive TiOBiosensors · 2022Article
- The Effect of Neddylation Blockade on Slug-Dependent Cancer Cell Migration Is Regulated by p53 Mutation Status.Cancers · 2021Article
- Clonal evolution driven by superdriver mutations.BMC evolutionary biology · 2020Article
- Edgetic perturbation signatures represent known and novel cancer biomarkers.Scientific reports · 2020Article
- Effects of ordered mutations on dynamics in signaling networks.BMC medical genomics · 2020Article
- Gene Signature Associated with Upregulation of the Wnt/β-Catenin Signaling Pathway Predicts Tumor Response to Transarterial Embolization.Journal of vascular and interventional radiology : JVIR · 2017Observational
- Dynamic changes of driver genes' mutations across clinical stages in nine cancer types.Cancer medicine · 2016Article
- Mutation Frequencies in Endometrial Cancer Patients of Different Ethnicities and Tumor Grades: An Analytical Study.Saudi journal of medicine & medical sciencesArticle
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1 author.
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Abstract
The driver genes play critical roles for tumorigenesis, and the number of identified driver genes reached plateau. But how they act during different cancer development stages is lack of knowledge. We investigated 138 driver genes' mutation changes across clinical stages using 3,477 cases in nine cancer types from the Cancer Genome Atlas (TCGA) and constructed their temporal order relationships. We also examined the codon changes for the widely mutated TP53 and PIK3CA in tumor stages. Combinations of one to three driver genes specifically dominated in each cancer. Across the clinical stages, we categorized three patterns for the behaviors of driver genes' mutation changes in the nine cancer types: recurrently mutated in all the stages and triggering other mutations; certain mutations lost meanwhile other mutations emerged; mutations dominated across entire stages, while other mutations gradually appeared or disappeared. We observed different codon changes dominated in different stages and revealed mutations recurrently occurring on the hotspot regions of the coding sequence may be the core factor for driver genes' tumorigenesis. Our results highlighted the dynamic changes of oncogenesis roles in different clinical stages and suggested different diagnostic decision making according to the clinical stages of patients.
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