ArticleEuropean heart journal. Cardiovascular Imaging2016
Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population.
Article in European heart journal. Cardiovascular Imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02968771 (Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolomic Profile of Patients Undergoing Myocardial Perfusion SPECT
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Vasodilator Myocardial Perfusion Cardiac Magnetic Resonance Imaging Is Superior to Dobutamine Stress Echocardiography in the Detection of Relevant Coronary Artery Stenosis: A Systematic Review and Meta-Analysis on Their Diagnostic Accuracy.Frontiers in cardiovascular medicine · 2021Pooled it
- Diagnostic Performance of Hybrid Cardiac Imaging Methods for Assessment of Obstructive Coronary Artery Disease Compared With Stand-Alone Coronary Computed Tomography Angiography: A Meta-Analysis.JACC. Cardiovascular imaging · 2018Pooled it
- Noninvasive fractional flow reserve derived from coronary computed tomography angiography for identification of ischemic lesions: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Influence of Cardiac CT based disease severity and clinical symptoms on the diagnostic performance of myocardial perfusion.The international journal of cardiovascular imaging · 2019Trial
- ChatGPT-4-Based Automated Preliminary Clinical Reporting in Myocardial Perfusion Imaging: A Pilot Evaluation.Diagnostics (Basel, Switzerland) · 2026Article
- [Nuclear medicine-necessity and opportunities in modern cardiology].Innere Medizin (Heidelberg, Germany) · 2026Review
- AI-enabled diagnosis and localization of myocardial ischemia and coronary artery stenosis from magnetocardiographic recordings.Scientific reports · 2025Article
- Recent Progress in Myocardial Perfusion Imaging Techniques.Nuclear medicine and molecular imaging · 2024Review
- Computed Tomography Angiography Identified High-Risk Coronary Plaques: From Diagnosis to Prognosis and Future Management.Diagnostics (Basel, Switzerland) · 2024Review
- Diagnostic Performance of Noninvasive Coronary Computed Tomography Angiography-Derived FFR for Coronary Lesion-Specific Ischemia Based on Deep Learning Analysis.Reviews in cardiovascular medicine · 2024Article
- Coronary physiology in the cath lab: is "virtual FFR" ready for the prime time?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Risk stratification of patients with INOCA: is perfusion PET imaging the game winner?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic impact of patients' management based on anatomic/functional phenotype: a study in patients with chronic coronary syndromes.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- 2023 Guidelines of the Taiwan Society of Cardiology on the Diagnosis and Management of Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2023Article
- Correlation of Morphological and Functional Cardiac Images: Fusion of Myocardial Perfusion SPECT and CT Angiography.Molecular imaging and radionuclide therapy · 2022Article
- Machine Learning Coronary Artery Disease Prediction Based on Imaging and Non-Imaging Data.Diagnostics (Basel, Switzerland) · 2022Article
- Dynamic ultrafast CZT imaging: Time for a paradigm change in myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Clinical significance of corrected relative flow reserve derived fromJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- MPI in the era of CZT cameras: Absolute numbers are still better than relative figures.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Network analysis of the left anterior descending coronary arteries in swim-trained rats by an in situ video microscopic technique.Biology of sex differences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors at 20 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. METHODS AND
resultsFourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with fractional flow reserve (FFR). Hybrid MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab analyses were performed for CTCA, MPS, QCA and hybrid datasets. Hemodynamically significant CAD was ruled-in non-invasively in the presence of a matched finding (myocardial perfusion defect co-localized with stenosed coronary artery) and ruled-out with normal findings (both CTCA and MPS normal). Overall prevalence of significant CAD on QCA (>70% stenosis or 30-70% with FFR≤0.80) was 37%. Of 1004 pathological myocardial segments on MPS, 246 (25%) were reclassified from their standard coronary distribution to another territory by hybrid imaging. In this respect, in 45/252 (18%) patients, hybrid imaging reassigned an entire perfusion defect to another coronary territory, changing the final diagnosis in 42% of the cases. Hybrid imaging allowed non-invasive CAD rule-out in 41%, and rule-in in 24% of patients, with a negative and positive predictive value of 88% and 87%, respectively.
conclusionIn patients at intermediate risk of CAD, hybrid imaging allows non-invasive co-localization of myocardial perfusion defects and subtending coronary arteries, impacting clinical decision-making in almost one every five subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.