Evidence map›Paper›PMID 26992238›Full record

ArticleOncotarget2016

Decreased MALL expression negatively impacts colorectal cancer patient survival.

Xiaoliang Wang, Junwei Fan, Fudong Yu, Feifei Cui, Xing Sun, Lin Zhong, Dongwang Yan, Chongzhi Zhou, Guilong Deng, Bin Wang and 11 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. A novel 12-gene signature as independent prognostic model in stage IA and IB lung squamous cell carcinoma patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Xiaoliang WangDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Junwei FanDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Fudong YuDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Feifei CuiDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Xing SunDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Lin ZhongDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Dongwang YanDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Chongzhi ZhouDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Guilong DengDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Bin WangDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Xiaosheng QiDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Shuyun WangDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Lei QuDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Biao DengDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Ming PanDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Jian ChenDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Yupeng WangDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Guohe SongDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Huamei TangDepartment of Pathology, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Zongguang ZhouDepartment of Gastrointestinal Surgery, Laboratory of Digestive Surgery of State Key Laboratory of Biotherapy, West China hospital, Sichuan University, Guo Xue Xiang, Chengdu, Sichuan China.
Zhihai PengDepartment of General Surgery, Shanghai First People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Jiao Tong University · CNShanghai First People's Hospital · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to determine whether MALL expression is associated with colon cancer progression and patient survival. MALL mRNA expression was reduced in the tumor tissues of 70% of the colon cancer patients and 75% of the rectal cancer patients as compared to their normal tissues. MALL protein was also significantly reduced in the tumor tissues of colon cancer patients (P < 0.001). Increased LOH and methylation of MALL was observed in tumor tissues as compared to normal tissues. Reduced MALL expression was associated with vessin invasion, disease recurrence and metastasis or death (P ≤ 0.027). Furthermore, patients with MALL-negative tumors had significantly decreased overall survival (OS) and disease-free survival (DFS) (P < 0.008 and P < 0.011, respectively). Univariate analysis indicated that MALL expression was significantly associated with OS and DFS. Finally, overexpression of MALL suppressed HCT116 and SW480 cell proliferation and inhibited HCT116 migration. MALL may play a role in colorectal cancer progression as suppression of its expression in tumor tissues negatively impacts colorectal cancer patient survival. Further analyses are required to determine if reduced MALL expression is due to LOH and/or methylation.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorColorectal NeoplasmsDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyelin and Lymphocyte-Associated Proteolipid ProteinsPrognosisProportional Hazards ModelsYoung AdultBiomarkers, TumorMALL protein, humanMyelin and Lymphocyte-Associated Proteolipid Proteinsbiomarkercolorectal cancermigrationsurvival

Identifiers

PMID26992238
PMCPMC5008411
OpenAlexW2342576707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.