ArticleOncotarget2016
Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Cell differentiation, aging, and death in spatially organized yeast communities: mechanisms and consequences.Cell death and differentiation · 2025Review
- Article
- Article
- The characteristics of differentiated yeast subpopulations depend on their lifestyle and available nutrients.Scientific reports · 2024Article
- Mitochondrial Research: Yeast and Human Cells as Models.International journal of molecular sciences · 2022Article
- Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies.International journal of molecular sciences · 2021Article
- Spatially structured yeast communities: Understanding structure formation and regulation with omics tools.Computational and structural biotechnology journal · 2021Review
- The Uprising of Mitochondrial DNA Biomarker in Cancer.Disease markers · 2021Review
- Analysis of Mitochondrial Retrograde Signaling in Yeast Model Systems.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops.International journal of molecular sciences · 2020Article
- Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death throughOxidative medicine and cellular longevity · 2019Article
- Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae.FEMS yeast research · 2018Review
- Article
- Long Noncoding RNAs in Yeast Cells and Differentiated Subpopulations of Yeast Colonies and Biofilms.Oxidative medicine and cellular longevity · 2018Review
- Transcriptome Remodeling of Differentiated Cells during Chronological Ageing of Yeast Colonies: New Insights into Metabolic Differentiation.Oxidative medicine and cellular longevity · 2018Article
- Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling.BMC genomics · 2017Article
- Meeting Report on Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems.G3 (Bethesda, Md.) · 2017Article
- Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.The Journal of cell biology · 2017Article
- Mitochondria in aging cell differentiation.Aging · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial retrograde signaling mediates communication from altered mitochondria to the nucleus and is involved in many normal and pathophysiological changes, including cell metabolic reprogramming linked to cancer development and progression in mammals. The major mitochondrial retrograde pathway described in yeast includes three activators, Rtg1p, Rtg2p and Rtg3p, and repressors, Mks1p and Bmh1p/Bmh2p. Using differentiated yeast colonies, we show that Mks1p-Rtg pathway regulation is complex and includes three branches that divergently regulate the properties and fate of three specifically localized cell subpopulations via signals from differently altered mitochondria. The newly identified RTG pathway-regulated genes ATO1/ATO2 are expressed in colonial upper (U) cells, the cells with active TORC1 that metabolically resemble tumor cells, while CIT2 is a typical target induced in one subpopulation of starving lower (L) cells. The viability of the second L cell subpopulation is strictly dependent on RTG signaling. Additional co-activators of Rtg1p-Rtg3p specific to particular gene targets of each branch are required to regulate cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.