Trial reportCritical care medicine2016
Long-Term Quality of Life Among Survivors of Severe Sepsis: Analyses of Two International Trials.
Trial report in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 7 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- [Prevention and treatment of long-term sequelae in critically ill patients-the responsibility of intensive care medicine].Die Anaesthesiologie · 2025Pooled it
- Health-Related Quality of Life of Adult Sepsis Survivors Following Critical Illness: A Systematic Review.Critical care explorations · 2025Pooled it
- Diagnostic models for sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Terlipressin for the treatment of septic shock in adults: a systematic review and meta-analysis.BMC anesthesiology · 2020Pooled it
- Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice.American journal of respiratory and critical care medicine · 2019Pooled it
- Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis.Critical care (London, England) · 2019Pooled it
- Pooled it
- Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial.American journal of respiratory and critical care medicine · 2026Trial
- A randomized clinical trial to evaluate the effect of post-intensive care multidisciplinary consultations on mortality and the quality of life at 1 year.Intensive care medicine · 2024Trial
- Trial
- Early use of high-dose vitamin C is beneficial in treatment of sepsis.Irish journal of medical science · 2021Trial
- Trial
- Cognitive Health and Quality of Life After Surviving Sepsis: A Narrative Review.Journal of intensive care medicine · 2026Review
- Mesenchymal Stromal Cell-Based Therapies in Sepsis-Induced Acute Lung and Kidney Injury: Current Advances and Perspectives.International journal of molecular sciences · 2026Review
- Evaluation for delirium and cognitive function in intensive care unit: reliability and validity of the Jikei Command following Scale in Japan.Acute and critical care · 2026Article
- Clinical Features and 1-Year Prognosis of Patients with Suspected Sepsis and Positive Blood Cultures in the Emergency Department: A Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
- Measuring health-related quality of life in sepsis survivors and caregivers: a mapping review and a preliminary conceptual framework.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Review
- β-Nicotinamide mononucleotide preserves muscle strength in septic male mice.Scientific reports · 2026Article
- Association Between Lactate and ICU-Acquired Infection in Critically Ill Patients With Sepsis: A Retrospective Study Using the MIMIC-IV Database.Journal of cellular and molecular medicine · 2026Article
- Impact of a Volunteer-Delivered Spiritual Care Strategy on Preventing Post-Intensive Care Syndrome-Family in Relatives of Critically Ill ICU Patients: A Quasi-Experimental Study.Nursing in critical care · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesTo describe the quality of life among sepsis survivors.
designSecondary analyses of two international, randomized clinical trials (A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis [derivation cohort] and PROWESS-SHOCK [validation cohort]).
settingICUs in North and South America, Europe, Africa, Asia, and Australia. PATIENTS: Adults with severe sepsis. We analyzed only patients who were functional and living at home without help before sepsis hospitalization (n = 1,143 and 987 from A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis and PROWESS-SHOCK, respectively).
interventionsNone. MEASUREMENTS AND MAIN
resultsIn A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis and PROWESS-SHOCK, the average age of patients living at home independently was 63 and 61 years; 400 (34.9%) and 298 (30.2%) died by 6 months. In A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis, 580 patients had a quality of life measured using EQ-5D at 6 months. Of these, 41.6% could not live independently (22.7% were home but required help, 5.1% were in nursing home or rehabilitation facilities, and 5.3% were in acute care hospitals). Poor quality of life at 6 months, as evidenced by problems in mobility, usual activities, and self-care domains were reported in 37.4%, 43.7%, and 20.5%, respectively, and the high incidence of poor quality of life was also seen in patients in PROWESS-SHOCK. Over 45% of patients with mobility and self-care problems at 6 months in A Controlled Comparison of Eritoran and placebo in patients with Severe Sepsis died or reported persistent problems at 1 year.
conclusionsAmong individuals enrolled in a clinical trial who lived independently prior to severe sepsis, one third had died and of those who survived, a further one third had not returned to independent living by 6 months. Both mortality and quality of life should be considered when designing new interventions and considering endpoints for sepsis trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.