Evidence map›Paper›PMID 26991889›Full record

ArticleThe American journal on addictions2016

Baseline medical comorbidities in adults randomized in the STRIDE trial for psychostimulant use disorders.

Adriane M Dela Cruz, Thomas Carmody, Tracy L Greer, Chad D Rethorst, Diane Warden, Robrina Walker, Madhukar H Trivedi

Open access · greenAbstract read
In one paragraph

Article in The American journal on addictions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adriane M Dela CruzDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Thomas CarmodyDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Tracy L GreerDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Chad D RethorstDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Diane WardenDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Robrina WalkerDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Madhukar H TrivediDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
The University of Texas Southwestern Medical Center · US

Funding

Project-004UG1DA020024 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI Steven J Shoptaw, MADHUKAR H. TRIVEDI · 2015 to 2026
$71.6M
Concept ProjectU10DA020024 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI TRIVEDI, MADHUKAR H. · 2005 to 2015
$22.6M
An Exercise Intervention to Prevent Interferon-Induced Depression in Hepatitis CK01MH097847 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI RETHORST, CHAD D · 2013 to 2016
$595k
NIDA NIH HHS U10 DA020024NIDA NIH HHS U10DA020024NIDA NIH HHS UG1 DA020024NIMH NIH HHS K01 MH097847NIMH NIH HHS K01MH097847
6 · The paper itself

Abstract

BACKGROUND AND

objectivesRates of medical illnesses may be higher among individuals with substance use disorders, complicating their care. This study aimed to expand the understanding of other medical conditions in treatment-seeking adults with stimulant use disorder (SUD) using data from Stimulant Reduction Intervention using Dose Exercise (STRIDE), a randomized, multisite trial investigating exercise augmentation of treatment as usual.

methodsUtilizing STRIDE baseline data, we examined demographic and clinical characteristics based on the number of self-reported diagnosed medical conditions among participants meeting eligibility criteria (passing medical screening exam and maximal exercise test, non-opioid dependent, no concomitant beta blocker, or opioid replacement therapy).

resultsThe majority (59%) of study participants (N = 302, mean age all participants = 39 years) did not report any history of other medical problems. Those with two or more conditions were older (mean age 46 years), reported more pain and worse physical functioning, and more psychiatric disorders (average 1.44). Hypertension was more common among participants with cocaine use disorders only (present in 16%) and liver disease was more common in those with cocaine plus other stimulant use disorders (present in 7%). CONCLUSION AND SCIENTIFIC SIGNIFICANCE: In this sample, patients with SUD were in surprisingly good health. A subpopulation had an overall higher burden of illness with worsened physical and psychiatric functioning. Provision of coordinated care may optimize treatment outcomes for patients based on medical comorbidity burden as well as type of drug abused, although these conclusions should be considered preliminary as they are based on self-reported data.

Indexed as

Randomized Controlled Trials as TopicAdultCentral Nervous System StimulantsComorbidityDiagnosis, Dual (Psychiatry)ExerciseExercise TherapyFemaleHumansHypertensionLiver DiseasesMaleMental DisordersMiddle AgedMulticenter Studies as TopicPainCentral Nervous System Stimulants

Identifiers

PMID26991889
PMCPMC4818002
OpenAlexW2297061391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.