Evidence map›Paper›PMID 26991691›Full record

ArticleClinical endocrinology2016

Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES.

Gabriella M Anic, Demetrius Albanes, Sabine Rohrmann, Norma Kanarek, William G Nelson, Gary Bradwin, Nader Rifai, Katherine A McGlynn, Elizabeth A Platz, Alison M Mondul

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Vitamin D and Male Erectile Function: An Updated Review.The world journal of men's health · 2021
    Review
  18. Article
  19. Vitamin D and Male Fertility: An Updated Review.The world journal of men's health · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Gabriella M AnicCancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Sabine RohrmannDivision of Chronic Disease Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Norma KanarekSidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
William G NelsonSidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Gary BradwinDepartment of Laboratory Medicine, Harvard Medical School and Children's Hospital, Boston, MA, USA.
Nader RifaiDepartment of Laboratory Medicine, Harvard Medical School and Children's Hospital, Boston, MA, USA.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Elizabeth A PlatzSidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Alison M MondulDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Division of Cancer Epidemiology and GeneticsBoston Children's Hospital · USSidney Kimmel Comprehensive Cancer Center · USJohns Hopkins University · USUniversity of Michigan–Ann Arbor · USUniversity of Zurich · CH

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5M
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

backgroundRecent literature suggests that high circulating vitamin D may increase prostate cancer risk. Although the mechanism through which vitamin D may increase risk is unknown, vitamin D concentration could influence circulating sex steroid hormones that may be associated with prostate cancer; an alternate explanation is that it could be associated with prostate-specific antigen (PSA) concentration causing detection bias.

objectiveWe examined whether serum vitamin D concentration was associated with sex steroid hormone and PSA concentrations in a cross-sectional analysis of men in the National Health and Nutrition Examination Surveys (NHANES).

designTestosterone, oestradiol, sex hormone-binding globulin (SHBG), androstanediol glucuronide, and 25-hydroxyvitamin D (25(OH)D) were measured in serum from men aged 20 and older participating in NHANES III (n = 1315) and NHANES 2001-2004 (n = 318). Hormone concentrations were compared across 25(OH)D quintiles, adjusting for age, race/ethnicity, body fat percentage, and smoking. PSA concentration was estimated by 25(OH)D quintile in 4013 men from NHANES 2001-2006.

resultsIn NHANES III, higher testosterone (quintile (Q) 1 = 17·2, 95% confidence interval (CI) = 16·1-18·6; Q5 = 19·6, 95% CI = 18·7-20·6 nmol/l, P-trend = 0·0002) and SHBG (Q1 = 33·8, 95% CI = 30·8-37·0; Q5 = 38·4, 95% CI = 35·8-41·2 nmol/l, P-trend = 0·0005) were observed with increasing 25(OH)D. Similar results were observed in NHANES 2001-2004. PSA concentration was not associated with serum 25(OH)D (P-trend = 0·34).

conclusionResults from these nationally representative studies support a positive association between serum 25(OH)D and testosterone and SHBG. The findings support an indirect mechanism through which vitamin D may increase prostate cancer risk, and suggest the link to prostate cancer is not due to PSA-detection bias.

Indexed as

Adipose TissueAdultBody Mass IndexCross-Sectional StudiesEthnicityGonadal Steroid HormonesHumansMaleProstate-Specific AntigenProstatic NeoplasmsRacial GroupsSex Hormone-Binding GlobulinVitamin DWaist Circumference25-hydroxyvitamin DGonadal Steroid HormonesProstate-Specific AntigenSex Hormone-Binding GlobulinVitamin D

Identifiers

PMID26991691
PMCPMC4946966
OpenAlexW2304714581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.