Evidence map›Paper›PMID 26991633›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016

Gd-TEMDO: Design, Synthesis, and MRI Application.

André Boltjes, Annadka Shrinidhi, Kees van de Kolk, Eberhardt Herdtweck, Alexander Dömling

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

André BoltjesDepartment of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, The Netherlands.
Annadka ShrinidhiDepartment of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, The Netherlands.
Kees van de KolkCentral Animal Facility, University of Groningen/UMCG, A. Deusinglaan 50, The Netherlands.
Eberhardt HerdtweckInstitut für Anorganische Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching bei München, Germany.
Alexander DömlingDepartment of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, The Netherlands. a.s.s.domling@rug.nl.
University of Groningen · NLTechnical University of Munich · DE

Funding

Real-time discovery of inhibitors among billion compounds for preview and downloadR01GM097082 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMACHO, CARLOS J. · 2011 to 2020
$2.5M
NIGMS NIH HHS R01 GM097082
6 · The paper itself

Abstract

A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to have a high complexation affinity with lanthanoid metals. Here we describe the design, synthesis, solid-state structure, binding constant, and some MRI applications of the Gd-TEMDO complex as the first example of a congeneric family of oligo-amino tetrazoles.

Indexed as

Contrast MediaCyclamsGadoliniumHeterocyclic CompoundsLigandsMagnetic Resonance ImagingMolecular StructureOrganometallic CompoundsTetrazoles1H-tetrazoleContrast MediaCyclamscyclenGadoliniumGd-TEMDOHeterocyclic CompoundsLigandsOrganometallic CompoundsTetrazolesgadoliniummacrocyclic ligandsmagnetic resonance imagingmulticomponent reactionsoligoamino tetrazole

Identifiers

PMID26991633
PMCPMC5363076
OpenAlexW2299373201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.