Evidence map›Paper›PMID 26991475›Full record

ReviewAmerican journal of respiratory and critical care medicine2016

Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis.

Robert Brownell, Naftali Kaminski, Prescott G Woodruff, Williamson Z Bradford, Luca Richeldi, Fernando J Martinez, Harold R Collard

Abstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Fibrosing interstitial lung diseases: knowns and unknowns.European respiratory review : an official journal of the European Respiratory Society · 2019
    Review
  10. Mechanisms for the Resolution of Organ Fibrosis.Physiology (Bethesda, Md.) · 2019
    Review
  11. Idiopathic Pulmonary Fibrosis (IPF): An Overview.Journal of clinical medicine · 2018
    Review
  12. Article
  13. Article
  14. Article
  15. Update in Interstitial Lung Disease 2016.American journal of respiratory and critical care medicine · 2017
    Article
  16. Observational
  17. Article
  18. Review
  19. Role of pirfenidone in the management of pulmonary fibrosis.Therapeutics and clinical risk management · 2017
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert Brownell1 Department of Medicine, University of California San Francisco, San Francisco, California.
Naftali Kaminski2 Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Prescott G Woodruff1 Department of Medicine, University of California San Francisco, San Francisco, California.
Williamson Z Bradford3 WZB Consulting, Wilson, Wyoming.
Luca Richeldi4 National Institute for Health Research Southampton Respiratory Biomedical Research Unit and Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom; and.
Fernando J Martinez5 Department of Medicine, Weill Cornell University School of Medicine, New York, New York.
Harold R Collard1 Department of Medicine, University of California San Francisco, San Francisco, California.

Funding

Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9M
Mir-29 mimicry as a therapy for pulmonary fibrosisUH2HL123886 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2014 to 2015
$2.7M
NHLBI NIH HHS R01 HL127349NHLBI NIH HHS UH2 HL123886
6 · The paper itself

Abstract

Precision medicine is defined by the National Institute of Health's Precision Medicine Initiative Working Group as an approach to disease treatment that takes into account individual variability in genes, environment, and lifestyle. There has been increased interest in applying the concept of precision medicine to idiopathic pulmonary fibrosis, in particular to search for genetic and molecular biomarker-based profiles (so called endotypes) that identify mechanistically distinct disease subgroups. The relevance of precision medicine to idiopathic pulmonary fibrosis is yet to be established, but we believe that it holds great promise to provide targeted and highly effective therapies to patients. In this manuscript, we describe the field's nascent efforts in genetic/molecular endotype identification and how environmental and behavioral subgroups may also be relevant to disease management.

Indexed as

HumansIdiopathic Pulmonary FibrosisPrecision Medicinebiological markersendotypesidiopathic pulmonary fibrosisprecision medicinestratified medicine

Identifiers

PMID26991475
PMCPMC5440061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.