Evidence map›Paper›PMID 26991298›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Susceptibility and molecular characterization of Candida species from patients with vulvovaginitis.

Gheniffer Fornari, Vania Aparecida Vicente, Renata Rodrigues Gomes, Marisol Dominguez Muro, Rosangela Lameira Pinheiro, Carolina Ferrari, Patricia Fernanda Herkert, Marcos Takimura, Newton Sérgio de Carvalho, Flavio Queiroz-Telles

Open access · hybridAbstract read
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Phenotypic and Molecular Characterization ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Characterization of OralAntibiotics (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Meyerozyma guilliermondii species complex: review of current epidemiology, antifungal resistance, and mechanisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Review
  8. Antifungal Activity of Natural Compounds vs.Antibiotics (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gheniffer FornariGraduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Laboratory of Microbiology and Molecular Biology-LabMicro, Federal University of Paraná, Curitiba, Paraná, Brazil.
Vania Aparecida VicenteGraduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Laboratory of Microbiology and Molecular Biology-LabMicro, Federal University of Paraná, Curitiba, Paraná, Brazil.
Renata Rodrigues GomesGraduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Laboratory of Microbiology and Molecular Biology-LabMicro, Federal University of Paraná, Curitiba, Paraná, Brazil.
Marisol Dominguez MuroSupport and Diagnosis Unit, Mycology Laboratory, Federal University of Paraná, Brazil.
Rosangela Lameira PinheiroSupport and Diagnosis Unit, Mycology Laboratory, Federal University of Paraná, Brazil.
Carolina FerrariClinical Hospital Federal University of Paraná, Brazil.
Patricia Fernanda HerkertGraduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Laboratory of Microbiology and Molecular Biology-LabMicro, Federal University of Paraná, Curitiba, Paraná, Brazil.
Marcos TakimuraClinical Hospital Federal University of Paraná, Brazil.
Newton Sérgio de CarvalhoClinical Hospital Federal University of Paraná, Brazil.
Flavio Queiroz-TellesGraduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Laboratory of Microbiology and Molecular Biology-LabMicro, Federal University of Paraná, Curitiba, Paraná, Brazil; Support and Diagnosis Unit, Mycology Laboratory, Federal University of Paraná, Brazil. Electronic address: Queiroz.telles@uol.com.br.
Universidade Federal do Paraná · BRHospital de Clínicas Universidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vulvovaginal candidiasis affects women of reproductive age, which represents approximately 15-25% of vaginitis cases. The present study aimed to isolate and characterize yeast from the patients irrespective of the presentation of clinical symptoms. The isolates were subjected to in vitro susceptibility profile and characterization by molecular markers, which intended to assess the distribution of species. A total of 40 isolates were obtained and identified through the CHROMagar, API20aux and by ITS and D1/D2 regions sequencing of DNAr gene. Candida albicans strains were genotyped by the ABC system and the isolates were divided into two genotypic groups. The identity of the C. albicans, C. glabrata, C. guilliermondii, C. kefyr and Saccharomyces cerevisiae isolates was confirmed by the multilocus analysis. The strains of Candida, isolated from patients with complications, were found to be resistant to nystatin but sensitive to fluconazole, amphotericin B and ketoconazole, as observed by in vitro sensitivity profile. The isolates from asymptomatic patients, i.e., the colonized group, showed a dose-dependent sensitivity to the anti-fungal agents, fluconazole and amphotericin B. However, the isolates of C. albicans that belong to distinct genotypic groups showed the same in vitro susceptibility profile.

Indexed as

AdolescentAdultAntifungal AgentsCandidaCandidiasis, VulvovaginalDrug Resistance, FungalFemaleFluconazoleHumansMicrobial Sensitivity TestsMiddle AgedPatientsYoung AdultAntifungal AgentsFluconazoleIn vitro susceptibilityVariability geneticVulvovaginal candidiasis

Identifiers

PMID26991298
PMCPMC4874609
OpenAlexW2325541447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.