ArticlePediatric research2016
Functional and structural connectivity of the visual system in infants with perinatal brain injury.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Using Functional Connectivity Magnetic Resonance Imaging to Measure Brain Connectivity in Preterm Infants.Nursing researchTrial
- Customization of neonatal functional magnetic resonance imaging: A preclinical phantom-based study.PloS one · 2024Article
- The role of early functional neuroimaging in predicting neurodevelopmental outcomes in neonatal encephalopathy.European journal of pediatrics · 2023Article
- Brain structural connectome in neonates with prenatal opioid exposure.Frontiers in neuroscience · 2022Article
- Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants.AJNR. American journal of neuroradiology · 2021Article
- Imaging the rapidly developing brain: Current challenges for MRI studies in the first five years of life.Developmental cognitive neuroscience · 2021Review
- Neonatal Functional and Structural Connectivity Are Associated with Cerebral Palsy at Two Years of Age.American journal of perinatology · 2020Article
- The relationship between biological and psychosocial risk factors and resting-state functional connectivity in 2-month-old Bangladeshi infants: A feasibility and pilot study.Developmental science · 2019Article
- Developmental changes in functional brain networks from birth through adolescence.Human brain mapping · 2019Article
- Altered functional network connectivity in preterm infants: antecedents of cognitive and motor impairments?Brain structure & function · 2018Article
- Thresholding functional connectomes by means of mixture modeling.NeuroImage · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfants with perinatal brain injury are at risk of later visual problems. Advanced neuroimaging techniques show promise to detect functional and structural alterations of the visual system. We hypothesized that infants with perinatal brain injury would have less brain activation during a visual functional magnetic resonance imaging (fMRI) task and reduced task-based functional connectivity and structural connectivity as compared with healthy controls.
methodsTen infants with perinatal brain injury and 20 control infants underwent visual fMRI and diffusion tensor imaging (DTI) during natural sleep with no sedation. Activation maps, functional connectivity maps, and structural connectivity were analyzed and compared between the two groups.
resultsMost infants in both groups had negative activation in the visual cortex during the fMRI task. Infants with brain injury showed reduced activation in the occipital cortex, weaker connectivity between visual areas and other areas of the brain during the visual task, and reduced fractional anisotropy in white matter tracts projecting to visual regions, as compared with control infants.
conclusionInfants with brain injury sustained in the perinatal period showed evidence of decreased brain activity and functional connectivity during a visual task and altered structural connectivity as compared with healthy term neonates.
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