Evidence map›Paper›PMID 26991251›Full record

ArticleJournal of digestive diseases2016

Longitudinal association of obesity, metabolic syndrome and diabetes with risk of elevated aminotransferase levels in a cohort of Mexican health workers.

Yvonne N Flores, Allyn Auslander, Catherine M Crespi, Michael Rodriguez, Zuo-Feng Zhang, Francisco Durazo, Jorge Salmerón

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of digestive diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Yvonne N FloresUnidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, Morelos, México.
Allyn AuslanderDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, California, USA.
Catherine M CrespiDepartment of Biostatistics, Center for Cancer Prevention and Control Research, Fielding School of Public Health and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Michael RodriguezDepartment of Family Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Zuo-Feng ZhangDepartment of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, California, USA.
Francisco DurazoDepartment of Digestive Diseases, David Geffen School of Medicine and Pfleger Liver Institute, UCLA, Los Angeles, California, USA.
Jorge SalmerónUnidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, Morelos, México.
UCLA Health · USCancer Research And Biostatistics · USCenter for Digestive and Liver Diseases · USInstituto Nacional de Salud Pública · MXMexican Social Security Institute · MXUniversity of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Genetic and Environmental Risk of Liver Disease/Cancer among MexicansK07CA197179 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FLORES, YVONNE NICOLE · 2015 to 2019
$805k
NCATS NIH HHS UL1 TR000124NCI NIH HHS K07 CA197179
6 · The paper itself

Abstract

objectiveIn Mexico, chronic liver disease have been increasingly found along with the rapidly growing prevalence of obesity, diabetes and metabolic syndrome (MS). We aimed to investigate the longitudinal association between these three factors and risk of elevated alanine aminotransferase (ALT) levels (>40 U/L), a marker for liver damage, in a cohort of Mexican adults.

methodsData were obtained from two separate waves of the Mexican Health Worker Cohort Study: Wave 1 (2004-2006) and Wave 2 (2011-2013). Unconditional logistic regression models were employed to determine the cross-sectional and longitudinal association between these risk factors and elevated ALT levels.

resultsThe prevalence of elevated ALT was significantly higher among men, individuals aged under 60 years, those who were overweight or obese, diabetic, with MS or heavy/binge drinkers. The longitudinal results indicated that weight gain between waves that resulted in a change in body mass index, along with remaining overweight or obese, were significantly associated with an increased risk of elevated ALT levels. A significantly increased risk of developing elevated ALT was also observed among those who acquired diabetes or MS from Wave 1 to Wave 2.

conclusionsWeight gain and acquiring diabetes or MS are associated with a significant risk of having elevated ALT. These results, within the context of the rapid increase in global obesity rates, call urgently for programs to help to prevent chronic liver disease.

Indexed as

AdultAgedAge FactorsAlanine TransaminaseAlcohol DrinkingBiomarkersBody Mass IndexChronic DiseaseCohort StudiesDiabetes Mellitus, Type 2FemaleHealth PersonnelHumansLiver DiseasesMaleMetabolic SyndromeAlanine TransaminaseBiomarkersdiabetesliver diseasesmetabolic syndromeMexicoobesity

Identifiers

PMID26991251
PMCPMC4956543
OpenAlexW2302177353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.