ArticlePhysical review letters2016
Emergent Collective Chemotaxis without Single-Cell Gradient Sensing.
Article in Physical review letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 106 citations in OpenAlex.
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- Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos.iScience · 2025Article
- Galvanotactic directionality of cell groups depends on group size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- An entropy-based approach for assessing the directional persistence of cell migration.Biophysical journal · 2024Article
- Effect of contact inhibition locomotion on confined cellular organization.Scientific reports · 2023Article
- Collective directional migration drives the formation of heteroclonal cancer cell clusters.Molecular oncology · 2023Article
- Collective chemotaxis in a Voronoi model for confluent clusters.Biophysical journal · 2022Article
- Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading.Soft matter · 2022Article
- Collective durotaxis of cohesive cell clusters on a stiffness gradient.The European physical journal. E, Soft matter · 2022Article
- Individual and collective foraging in autonomous search agents with human intervention.Scientific reports · 2021Article
- Article
- Rules of collective migration: from the wildebeest to the neural crest.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- A Micro-Optic Stalk (μOS) System to Model the Collective Migration of Retinal Neuroblasts.Micromachines · 2020Article
- Roles of Remote and Contact Forces in Epithelial Cell Structure Formation.Biophysical journal · 2020Article
- A Camera Sensors-Based System to Study Drug Effects On In Vitro Motility: The Case of PC-3 Prostate Cancer Cells.Sensors (Basel, Switzerland) · 2020Article
- Decoding collective communications using information theory tools.Journal of the Royal Society, Interface · 2020Article
- Modelling chase-and-run migration in heterogeneous populations.Journal of mathematical biology · 2020Article
- Dynamic instability and migration modes of collective cells in channels.Journal of the Royal Society, Interface · 2019Article
- Dynamic Migration Modes of Collective Cells.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Many eukaryotic cells chemotax, sensing and following chemical gradients. However, experiments show that even under conditions when single cells cannot chemotax, small clusters may still follow a gradient. This behavior is observed in neural crest cells, in lymphocytes, and during border cell migration in Drosophila, but its origin remains puzzling. Here, we propose a new mechanism underlying this "collective guidance," and study a model based on this mechanism both analytically and computationally. Our approach posits that contact inhibition of locomotion, where cells polarize away from cell-cell contact, is regulated by the chemoattractant. Individual cells must measure the mean attractant value, but need not measure its gradient, to give rise to directional motility for a cell cluster. We present analytic formulas for how the cluster velocity and chemotactic index depend on the number and organization of cells in the cluster. The presence of strong orientation effects provides a simple test for our theory of collective guidance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.