ArticlePloS one2016
Detection of Coxiella burnetii in Ambient Air after a Large Q Fever Outbreak.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics.Zoonoses and public health · 2019Pooled it
- Airborne geographical dispersal of Q fever from livestock holdings to human communities: a systematic review and critical appraisal of evidence.BMC infectious diseases · 2018Pooled it
- Updated systematic review: associations between proximity to animal feeding operations and health of individuals in nearby communities.Systematic reviews · 2017Pooled it
- Direct whole-genome sequencing of Coxiella burnetii from environmental samples using a two-step selective enrichment approach.PLoS neglected tropical diseases · 2026Article
- Human Q fever outbreak investigation and management in six European countries: a One Health compendium of practices and recommendations.CMI communications · 2026Review
- Surveillance of Q Fever in Dairy Cattle in Latvia: Molecular and Serological Findings and Association with Farm and Woodland Density.Microorganisms · 2026Article
- Molecular detection of Coxiella burnetii in vaginal and rectal swab samples of small ruminants from Kermanshah Province, western Iran.BMC veterinary research · 2026Article
- Article
- Molecular characterisation ofFrontiers in veterinary science · 2025Article
- Role of Goats in the Epidemiology ofBiology · 2022Review
- Performance Evaluation and Validation of Air Samplers To Detect Aerosolized Coxiella burnetii.Microbiology spectrum · 2022Article
- Establishing farm dust as a useful viral metagenomic surveillance matrix.Scientific reports · 2022Article
- Exposure of South African Abattoir Workers toTropical medicine and infectious disease · 2022Article
- Blood culture negative endocarditis in the modern era of 16S rRNA sequencing.Clinical medicine (London, England) · 2020Review
- Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates.Infection and immunity · 2019Article
- Insights into Livestock-Related Microbial Concentrations in Air at Residential Level in a Livestock Dense Area.Environmental science & technology · 2019Article
- Bovine abortion caused byJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Detection ofMicromachines · 2019Article
- Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility.PloS one · 2019Article
- A Q Fever Outbreak with a High Rate of Abortions at a Dairy Goat Farm: Coxiella burnetii Shedding, Environmental Contamination, and Viability.Applied and environmental microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the largest Q fever outbreaks ever occurred in the Netherlands from 2007-2010, with 25 fatalities among 4,026 notified cases. Airborne dispersion of Coxiella burnetii was suspected but not studied extensively at the time. We investigated temporal and spatial variation of Coxiella burnetii in ambient air at residential locations in the most affected area in the Netherlands (the South-East), in the year immediately following the outbreak. One-week average ambient particulate matter < 10 μm samples were collected at eight locations from March till September 2011. Presence of Coxiella burnetii DNA was determined by quantitative polymerase chain reaction. Associations with various spatial and temporal characteristics were analyzed by mixed logistic regression. Coxiella burnetii DNA was detected in 56 out of 202 samples (28%). Airborne Coxiella burnetii presence showed a clear seasonal pattern coinciding with goat kidding. The spatial variation was significantly associated with number of goats on the nearest goat farm weighted by the distance to the farm (OR per IQR: 1.89, CI: 1.31-2.76). We conclude that in the year after a large Q fever outbreak, temporal variation of airborne Coxiella burnetii is suggestive to be associated with goat kidding, and spatial variation with distance to and size of goat farms. Aerosol measurements show to have potential for source identification and attribution of an airborne pathogen, which may also be applicable in early stages of an outbreak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.