ArticleJournal of medicinal food2016
Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans.
Article in Journal of medicinal food, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with NAFLD: a randomized clinical trial.BMC complementary medicine and therapies · 2021Trial
- The Effect of Cranberry Consumption on Body Weight and Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Food science & nutrition · 2026Review
- The lifespan and healthspan extending effects of ellagic acid inFrontiers in aging · 2026Article
- Maral Root Extract and Its Main Constituent 20-Hydroxyecdysone Enhance Stress Resilience inInternational journal of molecular sciences · 2025Article
- Determination of health status during aging using bending and pumping rates at various survival rates in Caenorhabditis elegans.Scientific reports · 2025Article
- Black mulberry (Heliyon · 2025Article
- Article
- Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin-Anthocyanin Nanoparticles on High-FatFoods (Basel, Switzerland) · 2024Article
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- Litchi flower essential oil balanced lipid metabolism through the regulation of DAF-2/IIS, MDT-15/SBP-1, and MDT-15/NHR-49 pathway.Frontiers in nutrition · 2022Article
- Saponins from bitter melon reduce lipid accumulation via induction of autophagy inCurrent research in food science · 2022Article
- Curcumin reduced fat accumulation inCurrent research in food science · 2021Article
- Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation.Pharmaceutical research · 2021Article
- Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway inCurrent research in food science · 2020Article
- Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression.Biomolecules · 2020Review
- Epigallocatechin-3-Gallate Reduces Fat Accumulation inPreventive nutrition and food science · 2018Article
- Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons.GeroScience · 2018Article
- Article
- Lipid and Carbohydrate Metabolism inGenetics · 2017Review
- Piceatannol Reduces Fat Accumulation in Caenorhabditis elegans.Journal of medicinal food · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cranberry phenolic compounds have been linked to many health benefits. A recent report suggested that cranberry bioactives inhibit adipogenesis in 3T3-L1 adipocytes. Thus, we investigated the effects and mechanisms of the cranberry product (CP) on lipid metabolism using the Caenorhabditis elegans (C. elegans) model. CP (0.016% and 0.08%) dose-dependently reduced overall fat accumulation in C. elegans (N2, wild type) by 43% and 74%, respectively, without affecting its pumping rates or locomotive activities. CP decreased fat accumulation in aak-2 (an ortholog of AMP-activated kinase α) and tub-1 (an ortholog of TUBBY) mutants significantly, but only minimal effects were observed in sbp-1 (an ortholog of sterol response element-binding protein-1) and nhr-49 (an ortholog of peroxisome proliferator-activated receptor-α) mutant strains. We further confirmed that CP downregulated sbp-1, cebp, and hosl-1 (an ortholog of hormone-sensitive lipase homolog) expression, while increasing the expression of nhr-49 in wild-type C. elegans. These results suggest that CP could effectively reduce fat accumulation in C. elegans dependent on sbp-1, cebp, and nhr-49, but not aak-2 and tub-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.