Evidence map›Paper›PMID 26990771›Full record

ArticleJournal of medical virology2016

Molecular epidemiology identifies HIV transmission networks associated with younger age and heterosexual exposure among Korean individuals.

Bum Sik Chin, Antoine Chaillon, Sanjay R Mehta, Joel O Wertheim, Gayeon Kim, Hyoung-Shik Shin, Davey M Smith

Abstract read
In one paragraph

Article in Journal of medical virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bum Sik ChinCenter for Infectious Diseases, National Medical Center, Seoul, Republic of Korea.
Antoine ChaillonDepartment of Medicine, University of California San Diego, La Jolla, California.
Sanjay R MehtaDepartment of Medicine, University of California San Diego, La Jolla, California.
Joel O WertheimDepartment of Medicine, University of California San Diego, La Jolla, California.
Gayeon KimCenter for Infectious Diseases, National Medical Center, Seoul, Republic of Korea.
Hyoung-Shik ShinCenter for Infectious Diseases, National Medical Center, Seoul, Republic of Korea.
Davey M SmithDepartment of Medicine, University of California San Diego, La Jolla, California.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Molecular Epidemiology for HIV Prevention for Drug Users and Other Risk Groups DP1DA034978 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2016
$4.1M
A Multi-Site Investigation into the Effect of HIV Clade on Neurocognitive ImpairmR01MH083552 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2008 to 2012
$3.3M
Efficacy of ART to Interrupt HIV Transmission NetworksR01MH100974 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2014 to 2018
$3.2M
Mentoring Translational Research in HIVK24AI100665 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SMITH, DAVID MITCHELL · 2012 to 2021
$1.5M
Public Health Implications of HIV Transmission NetworksK01AI110181 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2014 to 2018
$668k
Molecular Epidemiology of HIV-1 in the California-Mexico Border RegionK23AI093163 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEHTA, SANJAY R · 2011 to 2015
$643k
NIAID NIH HHS K01 AI110181NIAID NIH HHS K23 AI093163NIAID NIH HHS K24 AI100665NIAID NIH HHS P30 AI036214NIDA NIH HHS DP1 DA034978NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH083552NIMH NIH HHS R01 MH100974
6 · The paper itself

Abstract

To evaluate if HIV transmission networks could be elucidated from data collected in a short time frame, 131 HIV-1 pol sequences were analyzed which were generated from treatment-naïve Korean individuals who were sequentially identified over 1 year. A transmission linkage was inferred when there was a genetic distance <1.5% and a total of 16 clusters, involving 39/131 (29.8%), were identified. Younger age and heterosexual exposure were independently related with clustering in the inferred network, which demonstrated that molecular epidemiology with currently generated data (i.e., drug resistance genotypes) can be used to identify local transmission networks, even over a short timeframe. J. Med. Virol. 88:1832-1835, 2016. © 2016 Wiley Periodicals, Inc.

Indexed as

HeterosexualityAdultAge FactorsCluster AnalysisDrug Resistance, ViralFemaleGenotypeHIV-1HIV InfectionsHomosexuality, MaleHumansMaleMiddle AgedMolecular EpidemiologyPhylogenypol Gene Products, Human Immunodeficiency Viruspol Gene Products, Human Immunodeficiency VirusRNA, Viralcluster analysishuman immunodeficiency virusmolecular epidemiologyphylogeny

Identifiers

PMID26990771
PMCPMC4969179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.