Evidence map›Paper›PMID 26990570›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2016

Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes.

B D Modena, S M Kurian, L W Gaber, J Waalen, A I Su, T Gelbart, T S Mondala, S R Head, S Papp, R Heilman and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02776111 (The Use of Microfluidics and Transcriptomics to Implement Precision Medicine in Post Solid Organ Transplant Patients), which is not on this map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02776111 terminatednot on this map

The Use of Microfluidics and Transcriptomics to Implement Precision Medicine in Post Solid Organ Transplant Patients

TypeobservationalSponsorUniversity of FloridaRan2016 to 2019Enrolled7ConditionsImmunosuppressionArmsBlood Sample
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 109 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 1 country.

B D ModenaDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
S M KurianDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
L W GaberDepartment of Pathology, The Methodist Hospital, Houston, TX.
J WaalenDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
A I SuDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
T GelbartDNA Microarray and Next Generation Sequencing Core, The Scripps Research Institute, La Jolla, CA.
T S MondalaDNA Microarray and Next Generation Sequencing Core, The Scripps Research Institute, La Jolla, CA.
S R HeadDNA Microarray and Next Generation Sequencing Core, The Scripps Research Institute, La Jolla, CA.
S PappDNA Microarray and Next Generation Sequencing Core, The Scripps Research Institute, La Jolla, CA.
R HeilmanTransplant Genomics Collaborative Group (TGCG), La Jolla, CA.
J J FriedewaldNorthwestern Comprehensive Transplant Center, Northwestern University, Chicago, IL.ORCID 0000-0002-9344-9928
S M FlechnerTransplant Genomics Collaborative Group (TGCG), La Jolla, CA.
C L MarshTransplant Genomics Collaborative Group (TGCG), La Jolla, CA.
R S SungTransplant Genomics Collaborative Group (TGCG), La Jolla, CA.
H ShidbanTransplant Genomics Collaborative Group (TGCG), La Jolla, CA.
L ChanTransplant Genomics Collaborative Group (TGCG), La Jolla, CA.
M M AbecassisNorthwestern Comprehensive Transplant Center, Northwestern University, Chicago, IL.ORCID 0000-0001-9333-463X
D R SalomonDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
Scripps Research Institute · USCollaborative Group (United States) · USNorthwestern University · USMethodist Hospital · USScripps Health · USSt Vincent Medical Center · USUniversity of Michigan–Ann Arbor · USWinnMed · US

Funding

Quantitative Biology CoreU19AI063603 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2004 to 2015
$26.4M
Scripps Translational Science InstituteKL2TR001112 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2013 to 2017
$3.0M
NCATS NIH HHS KL2 TR001112NIAID NIH HHS U19 AI063603
6 · The paper itself

Abstract

Interstitial fibrosis and tubular atrophy (IFTA) is found in approximately 25% of 1-year biopsies posttransplant. It is known that IFTA correlates with decreased graft survival when histological evidence of inflammation is present. Identifying the mechanistic etiology of IFTA is important to understanding why long-term graft survival has not changed as expected despite improved immunosuppression and dramatically reduced rates of clinical acute rejection (AR) (Services UDoHaH. http://www.ustransplant.org/annual_reports/current/509a_ki.htm). Gene expression profiles of 234 graft biopsy samples were obtained with matching clinical and outcome data. Eighty-one IFTA biopsies were divided into subphenotypes by degree of histological inflammation: IFTA with AR, IFTA with inflammation, and IFTA without inflammation. Samples with AR (n = 54) and normally functioning transplants (TX; n = 99) were used in comparisons. A novel analysis using gene coexpression networks revealed that all IFTA phenotypes were strongly enriched for dysregulated gene pathways and these were shared with the biopsy profiles of AR, including IFTA samples without histological evidence of inflammation. Thus, by molecular profiling we demonstrate that most IFTA samples have ongoing immune-mediated injury or chronic rejection that is more sensitively detected by gene expression profiling. These molecular biopsy profiles correlated with future graft loss in IFTA samples without inflammation.

Indexed as

Gene Expression ProfilingAtrophyFibrosisGlomerular Filtration RateGraft RejectionGraft SurvivalHumansKidney Failure, ChronicKidney Function TestsKidney TransplantationKidney TubulesNephritis, InterstitialPrognosisRisk FactorsSurvival Ratebasic (laboratory) research/sciencegenomicsgraft survivalimmunobiologyInterstitial fibrosis and tubular atrophykidney (allograft) function/dysfunctionkidney transplantation/nephrologyorgan transplantation in generalrejection: T cell mediated (TCMR)translational research/science

Identifiers

PMID26990570
PMCPMC5501990
OpenAlexW2299602226

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.