ArticleArthritis & rheumatology (Hoboken, N.J.)2016
Rate and Predisposing Factors for Sacroiliac Joint Radiographic Progression After a Two-Year Follow-up Period in Recent-Onset Spondyloarthritis.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Trial
- Evaluation of the change in structural radiographic sacroiliac joint damage after 2 years of etanercept therapy (EMBARK trial) in comparison to a contemporary control cohort (DESIR cohort) in recent onset axial spondyloarthritis.Annals of the rheumatic diseases · 2018Trial
- Progression of non-radiographic to radiographic axial spondyloarthritis: a risk model based on a chinese cohort study.BMC rheumatology · 2026Article
- The Effect of Clinical Knowledge on the Evaluation of Sacroiliac Joint Radiography in Patients with Spondyloarthritis.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Saudi Clinical Practice Guidelines for Management of Axial Spondyloarthritis Disease.Rheumatology and therapy · 2025Article
- Decoding the inflammatory-osteogenic axis in ankylosing spondylitis: mechanisms, dysregulation, and emerging therapeutic interventions.Frontiers in immunology · 2025Review
- Acetabular fracture pattern is altered by pre-injury sacroiliac joint autofusion.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- Risk of motor vehicle accidents with profound injuries in patients with ankylosing spondylitis: a nationwide, population-based cohort study.Therapeutic advances in musculoskeletal disease · 2024Article
- Clinical and structural damage outcomes in axial spondyloarthritis patients receiving NSAIDs or advanced therapies: a description of a real-life cohort.Frontiers in medicine · 2024Article
- The bone marrow side of axial spondyloarthritis.Nature reviews. Rheumatology · 2023Review
- Disease course of non-radiographic axial spondyloarthritis: Data from a long-term retrospective observational cohort.PloS one · 2023Observational
- Treatment of axial spondyloarthritis: an update.Nature reviews. Rheumatology · 2022Review
- A Real-World Study on the Effect of Imrecoxib for Patients with Axial Spondyloarthritis.Drug design, development and therapy · 2022Article
- Imaging in Axial Spondyloarthritis: What is Relevant for Diagnosis in Daily Practice?Current rheumatology reports · 2021Review
- Biological DMARDs and disease modification in axial spondyloarthritis: a review through the lens of causal inference.RMD open · 2021Review
- Non-radiographic axial spondyloarthritis in Tunisia: main characteristics and detailed comparison with ankylosing spondylitis.Clinical rheumatology · 2021Article
- Axial spondyloarthritis: concept, construct, classification and implications for therapy.Nature reviews. Rheumatology · 2021Review
- Structural changes in the sacroiliac joint on MRI and relationship to ASDAS inactive disease in axial spondyloarthritis: a 2-year study comparing treatment with etanercept in EMBARK to a contemporary control cohort in DESIR.Arthritis research & therapy · 2021Article
- The role of imaging in the diagnosis and management of axial spondyloarthritis.Nature reviews. Rheumatology · 2019Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the rate of radiographic structural progression in the sacroiliac (SI) joints in patients with radiographic or nonradiographic axial spondyloarthritis (SpA), and to determine factors predisposing to such progression, over 2 years.
methodsPatients with recent-onset axial SpA (from the Devenir des Spondyloarthropathies Indifferérenciées Récentes cohort) were assigned a radiographic SI joint score according to the modified New York criteria. Demographic characteristics, smoking status, HLA-B27 positivity, inflammation on magnetic resonance imaging (MRI) of the SI joints, disease activity, and treatment were investigated as potential predisposing factors. The main analysis consisted of the evaluation of the switch from nonradiographic to radiographic axial SpA, but other definitions of radiographic progression were also evaluated.
resultsOf the 708 patients enrolled, 449 had baseline and 2-year pelvic radiographs. Of these patients, 47% were men. Their mean ± SD age was 34 ± 9 years, 61% were B27 positive, and 37% had inflammation of the SI joints on MRI. The percentages of patients who switched from nonradiographic to radiographic axial SpA (4.9% [16 of 326]) and from radiographic to nonradiographic axial SpA (5.7% [7 of 123]) were low. The mean ± SD change in the total SI joint score (range 0-8) was small (0.1 ± 0.8) but highly significant (P < 0.001). The potential baseline predisposing factors for meeting the modified New York criteria in the multivariate analysis were current smoking, HLA-B27 positivity, and inflammation of the SI joints on MRI, with odds ratios of 3.3 (95% confidence interval [95% CI] 1.0-11.5], 12.6 (95% CI 2.3-274), and 48.8 (95% CI 9.3-904), respectively.
conclusionOur findings suggest that structural progression does exist in early SpA, but it is quite small and observed in a small number of patients, and that environmental (smoking status), genetic (HLA-B27 positivity), and inflammation (inflammation of the SI joints on MRI) markers might be independent predisposing factors for progression.
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