Evidence map›Paper›PMID 26990437›Full record

ArticleMolecular carcinogenesis2017

Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.

Erin P Madeen, Christiane V Löhr, Hannah You, Lisbeth K Siddens, Sharon K Krueger, Roderick H Dashwood, Frank J Gonzalez, William M Baird, Emily Ho, Lisa Bramer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.Drug metabolism and disposition: the biological fate of chemicals · 2018
    Review
  3. CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae.Mutation research. Genetic toxicology and environmental mutagenesis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Erin P MadeenDepartment of Molecular and Environmental Toxicology, Oregon State University, Corvallis, Oregon.
Christiane V LöhrCancer Prevention and Intervention Program, Linus Pauling Institute, Oregon State University, Corvallis, Oregon.
Hannah YouCancer Prevention and Intervention Program, Linus Pauling Institute, Oregon State University, Corvallis, Oregon.
Lisbeth K SiddensDepartment of Molecular and Environmental Toxicology, Oregon State University, Corvallis, Oregon.
Sharon K KruegerCancer Prevention and Intervention Program, Linus Pauling Institute, Oregon State University, Corvallis, Oregon.
Roderick H DashwoodCenter for Epigenetics and Disease Prevention, M.D. Anderson Cancer Center, Houston, Texas.
Frank J GonzalezCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland.
William M BairdDepartment of Molecular and Environmental Toxicology, Oregon State University, Corvallis, Oregon.
Emily HoCancer Prevention and Intervention Program, Linus Pauling Institute, Oregon State University, Corvallis, Oregon.
Lisa BramerSuperfund Research Program, Oregon State University, Corvallis, Oregon.
Katrina M WatersSuperfund Research Program, Oregon State University, Corvallis, Oregon.
David E WilliamsDepartment of Molecular and Environmental Toxicology, Oregon State University, Corvallis, Oregon.
Oregon State University · USOregon University System · USCenter for Cancer Research · USThe University of Texas MD Anderson Cancer Center · US

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Susan C Tilton · 2009 to 2026
$52.5M
Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
Xenobiotic ReceptorsZIABC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$16.4M
Transplacental Chemoprevention of Lung Tumors and LymphomasP01CA090890 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DASHWOOD, RODERICK H · 2003 to 2014
$14.2M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
NCI NIH HHS P01 CA090890NIEHS NIH HHS P30 ES000210NIEHS NIH HHS P42 ES016465NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

The cytochrome P450 (CYP) 1 family is active toward numerous environmental pollutants, including polycyclic aromatic hydrocarbons (PAHs). Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, we tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. Wild-type mCyp1b1, transgenic hCYP1B1 (mCyp1b1 null background), and mCyp1b1 null mice were assessed. Each litter had an equal number of siblings with Ahr

Indexed as

AnimalsCarcinogenesisCarcinogensChrysenesCytochrome P-450 CYP1B1FemaleGene Expression Regulation, NeoplasticHumansLungLung NeoplasmsMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPlacentaCarcinogensChrysenesCYP1B1 protein, humanCyp1b1 protein, mouseCytochrome P-450 CYP1B1dibenzo(b,def)chryseneCYP1B1 humanized micecytochrome P450 1B1PAH carcinogenesistransplacental cancer

Identifiers

PMID26990437
PMCPMC5457169
OpenAlexW2310265228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.