Evidence map›Paper›PMID 26990084›Full record

Trial reportJournal of child psychology and psychiatry, and allied disciplines2016

A randomized controlled trial of cognitive behavioral therapy for ADHD in medication-treated adolescents.

Susan E Sprich, Steven A Safren, Daniel Finkelstein, Jocelyn E Remmert, Paul Hammerness

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of child psychology and psychiatry, and allied disciplines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01019252 nacompletednot on this map

Compensatory Executive Functioning Skills Training in Adolescents With ADHD

TypeinterventionalSponsorMassachusetts General HospitalRan2009 to 2012Enrolled66ConditionsAttention Deficit Hyperactivity DisorderArmsCognitive Behavioral Therapy (CBT)
NCT02900144 nacompletednot on this map

Modified Comprehensive Behavioral Intervention for Tics: Treating Children With Tic Disorders, Co-occurring ADHD and Psychosocial Impairment

TypeinterventionalSponsorMassachusetts General HospitalRan2016 to 2019Enrolled17ConditionsTourette Syndrome, ADHDArmsModified Comprehensive Behavioral Intervention for Tics, Comprehensive Behavioral Intervention for Tics
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  10. Implementing Parent-Teen Motivational Interviewing + Behavior Therapy for ADHD in Community Mental Health.Prevention science : the official journal of the Society for Prevention Research · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Susan E SprichBehavioral Medicine Service, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Steven A SafrenBehavioral Medicine Service, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. ssafren@miami.edu.
Daniel FinkelsteinHarvard Medical School, Boston, MA, USA.
Jocelyn E RemmertBehavioral Medicine Service, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Paul HammernessHarvard Medical School, Boston, MA, USA.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Compensatory Executive Functioning Skills Training in Adolescents with ADHDR34MH083063 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SAFREN, STEVEN A, SPRICH, SUSAN · 2009 to 2011
$793k
NCRR NIH HHS UL1 RR025758NIMH NIH HHS R34 MH083063
6 · The paper itself

Abstract

objectiveTo test cognitive behavioral therapy (CBT) for persistent attention-deficit hyperactivity disorder (ADHD) symptoms in a sample of medication-treated adolescents.

methodsForty-six adolescents (ages 14-18), with clinically significant ADHD symptoms despite stable medication treatment were randomly assigned to receive CBT for ADHD or wait list control in a cross-over design. Twenty-four were randomized to CBT, 22 to wait list, and 15 crossed-over from wait list to CBT. A blind independent evaluator (IE) rated symptom severity on the ADHD Current Symptom Scale, by adolescent and parent report, and rated each subject using the Clinical Global Impression Severity Scale (CGI), a global measure of distress and impairment. These assessments were performed at baseline, 4-months (post-CBT or post wait list), and 8-months (post-treatment for those originally assigned to the wait list condition and 4-month follow-up for those originally assigned to CBT).

trial registrationhttp://clinicaltrials.gov/show/NCT01019252.

resultsUsing all available data, mixed effects modeling, and pooling for the wait list cross-over, participants who received CBT received a mean score 10.93 lower on the IE-rated parent assessment of symptom severity (95% CI: -12.93, -8.93; p < .0001), 5.24 lower on the IE-rated adolescent assessment of symptom severity (95% CI: -7.21, -3.28; p < .0001), and 1.17 lower IE-rated CGI (95% CI: -1.39, -.94; p < .0001). Results were consistent across 100 multiple imputations (all p < .0001). There was a greater proportion of responders after CBT by parent (50% vs. 18%, p = .00) and adolescent (58% vs. 18% p = .02) report.

conclusionsThis study demonstrates initial efficacy of CBT for adolescents with ADHD who continued to exhibit persistent symptoms despite medications.

Indexed as

Outcome Assessment, Health CareAdolescentAttention Deficit Disorder with HyperactivityCognitive Behavioral TherapyCross-Over StudiesFemaleHumansMaleSeverity of Illness IndexADHDadolescencebehavior therapycognitive therapy

Identifiers

PMID26990084
PMCPMC5026858

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.