ArticlePLoS computational biology2016
Feedback, Lineages and Self-Organizing Morphogenesis.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- The inherent fragility of collective proliferative control.iScience · 2025Article
- Data-driven spatio-temporal modelling of glioblastoma.Royal Society open science · 2023Review
- Steering particles via micro-actuation of chemical gradients using model predictive control.Biomicrofluidics · 2023Article
- Spatial dynamics of feedback and feedforward regulation in cell lineages.PLoS computational biology · 2022Article
- The global regulatory logic of organ regeneration: circuitry lessons from skin and its appendages.Biological reviews of the Cambridge Philosophical Society · 2021Article
- Regulatory feedback effects on tissue growth dynamics in a two-stage cell lineage model.Physical review. E · 2021Article
- Synthetic living machines: A new window on life.iScience · 2021Review
- Senescent cells and the incidence of age-related diseases.Aging cell · 2021Article
- Effect of feedback regulation on stem cell fractions in tissues and tumors: Understanding chemoresistance in cancer.Journal of theoretical biology · 2021Article
- Engineering organoids.Nature reviews. Materials · 2021Review
- Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes.eLife · 2020Article
- A Dynamical Paradigm for Molecular Cell Biology.Trends in cell biology · 2020Review
- Article
- Development and Arealization of the Cerebral Cortex.Neuron · 2019Review
- A multiscale mathematical model of cell dynamics during neurogenesis in the mouse cerebral cortex.BMC bioinformatics · 2019Article
- Stem cell bioengineering: building from stem cell biology.Nature reviews. Genetics · 2018Review
- Stability of Control Networks in Autonomous Homeostatic Regulation of Stem Cell Lineages.Bulletin of mathematical biology · 2018Article
- Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth.Bulletin of mathematical biology · 2018Article
- Programming Morphogenesis through Systems and Synthetic Biology.Trends in biotechnology · 2018Review
- Determining the control networks regulating stem cell lineages in colonic crypts.Journal of theoretical biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Feedback regulation of cell lineage progression plays an important role in tissue size homeostasis, but whether such feedback also plays an important role in tissue morphogenesis has yet to be explored. Here we use mathematical modeling to show that a particular feedback architecture in which both positive and negative diffusible signals act on stem and/or progenitor cells leads to the appearance of bistable or bi-modal growth behaviors, ultrasensitivity to external growth cues, local growth-driven budding, self-sustaining elongation, and the triggering of self-organization in the form of lamellar fingers. Such behaviors arise not through regulation of cell cycle speeds, but through the control of stem or progenitor self-renewal. Even though the spatial patterns that arise in this setting are the result of interactions between diffusible factors with antagonistic effects, morphogenesis is not the consequence of Turing-type instabilities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.