ArticlePloS one2016
Dynamic Mechanical and Nanofibrous Topological Combinatory Cues Designed for Periodontal Ligament Engineering.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Stem cell-driven biomedical technologies for tooth regeneration: engineering scaffolds, organoid models, and molecular targeted strategies.Stem cell research & therapy · 2026Review
- Reimagining periodontal regeneration: smart biomaterials for a complex tissue landscape.Regenerative biomaterials · 2026Review
- Potential of Trilayered Gelatin/Polycaprolactone Nanofibers for Periodontal Regeneration: An In Vitro Study.International journal of molecular sciences · 2025Article
- Hierarchical Biomaterial Scaffolds for Periodontal Tissue Engineering: Recent Progress and Current Challenges.International journal of molecular sciences · 2024Review
- Direct-Writing Electrospun Functionalized Scaffolds for Periodontal Regeneration: In Vitro Studies.Journal of functional biomaterials · 2023Article
- A Review of Biomimetic and Biodegradable Magnetic Scaffolds for Bone Tissue Engineering and Oncology.International journal of molecular sciences · 2023Review
- A Review of In Vivo and Clinical Studies Applying Scaffolds and Cell Sheet Technology for Periodontal Ligament Regeneration.Biomolecules · 2022Review
- Combined Application of Prototype Ultrasound and BSA-Loaded PLGA Particles for Protein Delivery.Pharmaceutical research · 2021Article
- 3D-Printed Collagen-Based Waveform Microfibrous Scaffold for Periodontal Ligament Reconstruction.International journal of molecular sciences · 2021Article
- Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration: A Literature Review.Journal of clinical medicine · 2020Review
- Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration.Tissue engineering and regenerative medicine · 2020Article
- Recent advances in periodontal regeneration: A biomaterial perspective.Bioactive materials · 2020Article
- A Critical Review on the Production of Electrospun Nanofibres for Guided Bone Regeneration in Oral Surgery.Nanomaterials (Basel, Switzerland) · 2019Review
- Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms.International journal of molecular sciences · 2019Review
- Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.Inflammation · 2019Article
- Advance of Nano-Composite Electrospun Fibers in Periodontal Regeneration.Frontiers in chemistry · 2019Review
- Potential strain-dependent mechanisms defining matrix alignment in healing tendons.Biomechanics and modeling in mechanobiology · 2018Article
- Bone remodeling induced by mechanical forces is regulated by miRNAs.Bioscience reports · 2018Review
- Trends in polymeric electrospun fibers and their use as oral biomaterials.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Influence of Micropatterning on Human Periodontal Ligament Cells' Behavior.Biophysical journal · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complete reconstruction of damaged periodontal pockets, particularly regeneration of periodontal ligament (PDL) has been a significant challenge in dentistry. Tissue engineering approach utilizing PDL stem cells and scaffolding matrices offers great opportunity to this, and applying physical and mechanical cues mimicking native tissue conditions are of special importance. Here we approach to regenerate periodontal tissues by engineering PDL cells supported on a nanofibrous scaffold under a mechanical-stressed condition. PDL stem cells isolated from rats were seeded on an electrospun polycaprolactone/gelatin directionally-oriented nanofiber membrane and dynamic mechanical stress was applied to the cell/nanofiber construct, providing nanotopological and mechanical combined cues. Cells recognized the nanofiber orientation, aligning in parallel, and the mechanical stress increased the cell alignment. Importantly, the cells cultured on the oriented nanofiber combined with the mechanical stress produced significantly stimulated PDL specific markers, including periostin and tenascin with simultaneous down-regulation of osteogenesis, demonstrating the roles of topological and mechanical cues in altering phenotypic change in PDL cells. Tissue compatibility of the tissue-engineered constructs was confirmed in rat subcutaneous sites. Furthermore, in vivo regeneration of PDL and alveolar bone tissues was examined under the rat premaxillary periodontal defect models. The cell/nanofiber constructs engineered under mechanical stress showed sound integration into tissue defects and the regenerated bone volume and area were significantly improved. This study provides an effective tissue engineering approach for periodontal regeneration-culturing PDL stem cells with combinatory cues of oriented nanotopology and dynamic mechanical stretch.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.