ReviewBioMed research international2016
Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction.
Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antibiotic exposure and risk of type 2 diabetes mellitus: a systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- Comparative validation of LC-MS, micro-bioassay, and ELISA for lincomycin quantification: application to pharmacokinetic analysis in healthy and co-infected porcine models.The veterinary quarterly · 2026Article
- A population pharmacokinetic study of ampicillin therapy in hospitalized foals.Journal of veterinary internal medicine · 2026Article
- Anti-Inflammatory and Antioxidant Effects of Quercetin, Luteolin, and Proanthocyanidins in Canine PBMCs Stimulated withAnimals : an open access journal from MDPI · 2025Article
- Pharmacodynamic Profiling of Amoxicillin: Targeting Multidrug-Resistant Gram-Positive PathogensAntibiotics (Basel, Switzerland) · 2025Article
- Pharmacokinetics/pharmacodynamics of gamithromycin for treating Pasteurella multocida infection in cattle using a tissue cage model.PloS one · 2025Article
- Comparison of the Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and 7 Other Antimicrobial Agents Tested Against Swine Isolates ofMolecules (Basel, Switzerland) · 2024Article
- Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates ofPathogens (Basel, Switzerland) · 2024Article
- Combination therapy synergism prediction for virus treatment using machine learning models.PloS one · 2024Article
- Design, synthesis, biological evaluation and molecular docking study of novel pleuromutilin derivatives containing substituted benzoxazole as antibacterial agents.Journal of enzyme inhibition and medicinal chemistry · 2023Article
- A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs.PLoS computational biology · 2023Article
- Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kgAntibiotics (Basel, Switzerland) · 2023Article
- The pharmacokinetics and pharmacodynamics of cefquinome against Streptococcus agalactiae in a murine mastitis model.PloS one · 2023Article
- PK/PD Analysis by Nonlinear Mixed-Effects Modeling of a Marbofloxacin Dose Regimen for Treatment of Goat Mastitis Produced by Coagulase-Negative Staphylococci.Animals : an open access journal from MDPI · 2021Article
- Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling.BMC veterinary research · 2021Article
- The Role of PK/PD Analysis in the Development and Evaluation of Antimicrobials.Pharmaceutics · 2021Review
- Determination of Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Parameters of Doxycycline againstAntibiotics (Basel, Switzerland) · 2021Article
- Prudent Use of Tylosin for Treatment ofFrontiers in microbiology · 2021Article
- Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents.Journal of veterinary science · 2019Review
- PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs.BMC veterinary research · 2019Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among veterinary drugs, antibiotics are frequently used. The true mean of antibiotic treatment is to administer dose of drug that will have enough high possibility of attaining the preferred curative effect, with adequately low chance of concentration associated toxicity. Rising of antibacterial resistance and lack of novel antibiotic is a global crisis; therefore there is an urgent need to overcome this problem. Inappropriate antibiotic selection, group treatment, and suboptimal dosing are mostly responsible for the mentioned problem. One approach to minimizing the antibacterial resistance is to optimize the dosage regimen. PK/PD model is important realm to be used for that purpose from several years. PK/PD model describes the relationship between drug potency, microorganism exposed to drug, and the effect observed. Proper use of the most modern PK/PD modeling approaches in veterinary medicine can optimize the dosage for patient, which in turn reduce toxicity and reduce the emergence of resistance. The aim of this review is to look at the existing state and application of PK/PD in veterinary medicine based on in vitro, in vivo, healthy, and disease model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.