ArticleTremor and other hyperkinetic movements (New York, N.Y.)2016
Non-Motor Symptoms of Essential Tremor Are Independent of Tremor Severity and Have an Impact on Quality of Life.
Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Essential tremor patients experience significant burden beyond tremor: A systematic literature review.Frontiers in neurology · 2022Pooled it
- Magnetic Resonance-Guided Focused Ultrasound Neurosurgery for Essential Tremor: A Health Technology Assessment.Ontario health technology assessment series · 2018Pooled it
- Clinical Features of Essential Tremor and its Impact on Quality of Life in Japan.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Exploring serum α‑synuclein and its autoantibodies in essential tremor: implications for diagnosis and symptom correlations.Biomedical reports · 2024Article
- Motor features associated with cognition in non-demented individuals with essential tremor.Journal of the neurological sciences · 2022Article
- Primidone Intolerance in Essential tremor: Is it More than Just Age?Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Review
- Current Opinions and Consensus for Studying Tremor in Animal Models.Cerebellum (London, England) · 2019Review
- Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Article
- Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Article
- Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures.Parkinsonism & related disorders · 2017Article
- Computational modeling to improve treatments for essential tremor.Drug discovery today. Disease models · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral publications have focused on accompanying non-motor symptoms (NMS) in essential tremor (ET) patients; however, it remains unclear if NMS are an intrinsic part of the disease or secondary phenomena. We present the results of several neuropsychiatric tests and their impact on quality of life (QoL) in community-dwelling patients with ET.
methodsParticipants were recruited via a newspaper article about ET published in the local media and on the internet. All participants completed several standard neuropsychiatric tests, including those that assess QoL. To compare differences between cases and controls, Student's t-tests with Bonferroni-Holm post hoc tests were performed. Spearman's correlation coefficients were also calculated.
resultsWe enrolled 110 patients with definite or probable ET. Highly significant changes were observed for apathy, anxiety, and cognition and negatively impacted QoL. Most aberrations were independent of tremor severity and duration. DISCUSSION: The significant neuropsychiatric deficits and reduced QoL demonstrate a degree of illness that appears to be a non-motor phenotype rather than a secondary effect of ET. In the future, NMS should carefully be explored in ET patients as they may have an impact on QoL and treatment.
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