ArticleEvolutionary applications2016
Predation and selection for antibiotic resistance in natural environments.
Article in Evolutionary applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Survival and spread of engineeredApplied and environmental microbiology · 2025Article
- Protistan predation selects for antibiotic resistance in soil bacterial communities.The ISME journal · 2023Article
- NaturalizedFrontiers in microbiology · 2022Review
- Recent advances in exploring the heavy metal(loid) resistant microbiome.Computational and structural biotechnology journal · 2021Review
- Weakest-Link Dynamics Predict Apparent Antibiotic Interactions in a Model Cross-Feeding Community.Antimicrobial agents and chemotherapy · 2020Article
- Globally Abundant "mSphere · 2020Article
- Inhibitory interaction networks among coevolved Streptomyces populations from prairie soils.PloS one · 2019Article
- The Threat of Antimicrobial Resistance on the Human Microbiome.Microbial ecology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes encoding resistance to antibiotics appear, like the antibiotics themselves, to be ancient, originating long before the rise of the era of anthropogenic antibiotics. However, detailed understanding of the specific biological advantages of antibiotic resistance in natural environments is still lacking, thus limiting our efforts to prevent environmental influx of resistance genes. Here, we propose that antibiotic-resistant cells not only evade predation from antibiotic producers but also take advantage of nutrients released from cells that are killed by the antibiotic-producing bacteria. Thus, predation is potentially an important mechanism for driving antibiotic resistance during slow or stationary phase of growth when nutrients are deprived. This adds to explain the ancient nature and widespread occurrence of antibiotic resistance in natural environments unaffected by anthropogenic antibiotics. In particular, we suggest that nutrient-poor environments including indoor environments, for example, clean rooms and intensive care units may serve as a reservoir and source for antibiotic-producing as well as antibiotic-resistant bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.