Evidence map›Paper›PMID 26989270›Full record

ArticleTetrahedron letters2016

Synthesis of extended oxazoles II: Reaction manifold of 2-(halomethyl)-4,5-diaryloxazoles.

Pravin C Patil, Frederick A Luzzio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Continuous multistep synthesis of 2-(azidomethyl)oxazoles.Beilstein journal of organic chemistry · 2018
    Article
  4. Selective alkylation/oxidation ofTetrahedron letters · 2017
    Article
  5. Article
  6. Tetrahedron letters · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pravin C PatilDepartment of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, Kentucky, 40292 USA.
Frederick A LuzzioDepartment of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, Kentucky, 40292 USA.
University of Louisville · US

Funding

Structure-based design and synthesis of peptidominetics targeting P. gingivalisR01DE023206 · NIDCR · UNIVERSITY OF LOUISVILLE · PI DEMUTH, DONALD R, LUZZIO, FREDERICK ANTHONY · 2013 to 2017
$1.9M
NIDCR NIH HHS R01 DE023206
6 · The paper itself

Abstract

2-(Halomethyl)-4,5-diphenyloxazoles are effective, reactive scaffolds which can be utilized for synthetic elaboration at the 2-position. Through substitution reactions, the chloromethyl analogue is used to prepare a number of 2-alkylamino-, 2-alkylthio- and 2-alkoxy-(methyl) oxazoles. The 2-bromomethyl analogue offers a more reactive alternative to the chloromethyl compounds and is useful in the C-alkylation of a stabilized (malonate) carbanion as exemplified by a concise synthesis of Oxaprozin.

Indexed as

click chemistryheterocyclesligandsOxaprozinoxazoles

Identifiers

PMID26989270
PMCPMC4790446
OpenAlexW2227540339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.