ArticleDevelopment (Cambridge, England)2016
Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
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- A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration.Development (Cambridge, England) · 2025Article
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- Activation of fetal-like molecular programs during regeneration in the intestine and beyond.Cell stem cell · 2024Review
- Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation.Science advances · 2023Article
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- TACSTD2 upregulation is an early reaction to lung infection.Scientific reports · 2022Article
- Changes in progenitors and differentiated epithelial cells of neonatal piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Cold atmospheric plasma differentially affects cell renewal and differentiation of stem cells and APC-deficient-derived tumor cells in intestinal organoids.Cell death discovery · 2022Article
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- Cellular origins and lineage relationships of the intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Active elimination of intestinal cells drives oncogenic growth in organoids.Cell reports · 2021Article
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- Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2Frontiers in medicine · 2021Article
- Trop2: Jack of All Trades, Master of None.Cancers · 2020Review
- Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa.The Journal of pathology · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse fetal intestinal progenitors lining the epithelium prior to villogenesis grow as spheroids when cultured ex vivo and express the transmembrane glycoprotein Trop2 as a marker. Here, we report the characterization of Trop2-expressing cells from fetal pre-glandular stomach, growing as immortal undifferentiated spheroids, and their relationship with gastric development and regeneration. Trop2(+) cells generating gastric spheroids differed from adult glandular Lgr5(+) stem cells, but appeared highly related to fetal intestinal spheroids. Although they shared a common spheroid signature, intestinal and gastric fetal spheroid-generating cells expressed organ-specific transcription factors and were committed to intestinal and glandular gastric differentiation, respectively. Trop2 expression was transient during glandular stomach development, being lost at the onset of gland formation, whereas it persisted in the squamous forestomach. Undetectable under homeostasis, Trop2 was strongly re-expressed in glands after acute Lgr5(+) stem cell ablation or following indomethacin-induced injury. These highly proliferative reactive adult Trop2(+) cells exhibited a transcriptome displaying similarity with that of gastric embryonic Trop2(+) cells, suggesting that epithelium regeneration in adult stomach glands involves the partial re-expression of a fetal genetic program.
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