Evidence map›Paper›PMID 26989097›Full record

Trial reportThe British journal of psychiatry : the journal of mental science2016

Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.

Jonathan R I Coleman, Kathryn J Lester, Robert Keers, Susanna Roberts, Charles Curtis, Kristian Arendt, Susan Bögels, Peter Cooper, Cathy Creswell, Tim Dalgleish and 21 more

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  7. Article
  8. Patterns of sub-optimal change following CBT for childhood anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Article
  9. Transcriptomics and psychotherapy: An integrative review.Brain, behavior, & immunity - health · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Genetics of Anxiety Disorders.Current psychiatry reports · 2019
    Review
  18. Article
  19. From neuroscience to evidence based psychological treatments - The promise and the challenge, ECNP March 2016, Nice, France.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jonathan R I ColemanJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Kathryn J LesterJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Robert KeersJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Susanna RobertsJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Charles CurtisJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Kristian ArendtJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Susan BögelsJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Peter CooperJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Cathy CreswellJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Tim DalgleishJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Catharina A HartmanJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Einar R HeiervangJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Katrin HötzelJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Jennifer L HudsonJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Tina In-AlbonJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Kristen LavalleeJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Heidi J LynehamJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Carla E MarinJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Richard Meiser-StedmanJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Talia MorrisJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Maaike H NautaJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Ronald M RapeeJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Silvia SchneiderJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Sophie C SchneiderJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Wendy K SilvermanJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Mikael ThastumJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Kerstin ThirlwallJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Polly WaiteJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Gro Janne WergelandJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Gerome BreenJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S
Thalia C EleyJonathan R. I. Coleman, MSc, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, UK; Kathryn J. Lester, DPhil, King's College London, IoPPN, MRC SGDP Centre, UK, and School of Psychology, University of Sussex, UK; Robert Keers, PhD, Susanna Roberts, MSc, King's College London, IoPPN, MRC SGDP Centre, UK; Charles Curtis, MSc, King's College London, IoPPN, MRC SGDP Centre, UK, and National Institute for Health Research Biomedical Research Centre, South London and Maudsley National Health Service Trust, UK; Kristian Arendt, PhD, Department of Psychology and Behavioural Sciences, Aarhus University, Denmark; Susan Bögels, PhD, Research Institute Child Development and Education, University of Amsterdam, The Netherlands; Peter Cooper, DPhil, School of Psychology and Clinical Language Sciences, University of Reading, UK, and Department of Psychology, Stellenbosch University, South Africa; Cathy Creswell, DClinPsy, PhD, School of Psychology and Clinical Language Sciences, University of Reading, UK; Tim Dalgleish, PhD, MRC Cognition & Brain Sciences Unit, Cambridge, UK; Catharina A. Hartman, PhD, Department of Psychiatry, University of Groningen, University Medical Center Groningen, The Netherlands; Einar R. Heiervang, PhD, Institute of Clinical Medicine, University of Oslo, Norway; Katrin Hötzel, PhD, Department of Psychology, Ruhr-Universität Bochum, Germany; Jennifer L. Hudson, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Tina In-Albon, PhD, Clinical Child and Adolescent Psychology, Universität Koblenz-Landau, Germany; Kristen Lavallee, PhD, Department of Psychology, University of Basel, Switzerland; Heidi J. Lyneham, PhD, Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia; Carla E. Marin, PhD, Yale University, Child Study Center, New Haven, Connecticut, USA; Richard Meiser-S

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Parent Mediation of Child Anxiety CBT OutcomeR01MH079943 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI PETTIT, JEREMY W · 2008 to 2012
$3.0M
Department of Health PB-PG-0107-12042Department of Health PB-PG-0110-21190Department of Health RP_2014-04-018Medical Research Council G0601020Medical Research Council G0601874Medical Research Council G0802326Medical Research Council G0901874Medical Research Council G1002011Medical Research Council MC_EX_G0802821Medical Research Council MC_U105579215Medical Research Council MR/K021281/1Medical Research Council MR/K021281/2NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH079943
6 · The paper itself

Abstract

backgroundAnxiety disorders are common, and cognitive-behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.

aimsTo perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).

methodPresence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up.

resultsNo variants passed a genome-wide significance threshold (P = 5 × 10(-8)) in either analysis. Four variants met criteria for suggestive significance (P<5 × 10(-6)) in association with response post-treatment, and three variants in the 6-month follow-up analysis.

conclusionsThis is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.

Indexed as

Cognitive Behavioral TherapyGenome-Wide Association StudyAdolescentAnxiety DisordersChildChild, PreschoolFemaleGenotypeHumansMalePolymorphism, Single NucleotideTreatment Outcome

Identifiers

PMID26989097
PMCPMC5007453

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