Evidence map›Paper›PMID 26988924›Full record

ArticleOral diseases2016

Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis.

C J Poston, T C Pierce, Y Li, C W Brinson, Z Lu, A W Lauer, R S Leite, Y Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Periodontitis and cardiovascular diseases: Consensus report.Journal of clinical periodontology · 2020
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C J PostonDivision of Periodontics, Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA.
T C PierceDivision of Periodontics, Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA.
Y LiDivision of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
C W BrinsonDivision of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Z LuRalph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA.
A W LauerDivision of Biostatistics, Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
R S LeiteDivision of Periodontics, Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, SC, USA.
Y HuangDivision of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

The Effect of Statin on Diabetes-Associated Peridontal DiseaseR01DE016353 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HUANG, YAN · 2005 to 2014
$3.3M
Toll-Like Receptors and Atherosclerosis in DiabetesI01BX000854 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI HUANG, YAN · 2011 to 2018
–
BLRD VA I01 BX000854Intramural VA VA999999NIDCR NIH HHS R01 DE016353
6 · The paper itself

Abstract

backgroundThis study was conducted to assess whether statin intake is associated with clinical parameters of periodontitis and matrix metalloproteinase (MMP) levels in gingival crevicular fluid (GCF) of non-diabetic and diabetic patients.

methodsWe first determined the effect of simvastatin on MMP expression in mononuclear cells. We then recruited 117 non-diabetic and diabetic patients, who all had periodontitis and took or did not take statin, and measured periodontal probing depth (PPD) and clinical attachment level (CAL), and collected gingival crevicular fluid (GCF) to quantify MMPs.

resultsThe in vitro studies showed that simvastatin potently inhibited the expression of MMP-1, MMP-8, and MMP-9 upregulated by lipopolysaccharide (LPS) and high glucose in mononuclear cells. The patient study showed that, after adjusting for age and smoking status, PPD in diabetic patients on statin was significantly less than that in diabetic patients not on statin. MMP-1 level in GCF of non-diabetic and diabetic patients on statin was lower than that of non-diabetic and diabetic patients not on statin, respectively. No difference was found for MMP-8 and -9 levels in GCF.

conclusionStatin intake is associated with reduced PPD in diabetic patients and MMP-1 level in GCF in either non-diabetic or diabetic patients.

Indexed as

AdultAgedBlood GlucoseCollagenasesDiabetes ComplicationsDiabetes MellitusFemaleGingival Crevicular FluidHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLipopolysaccharidesMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 8Matrix Metalloproteinase 9Middle AgedBlood GlucoseCollagenasesHydroxymethylglutaryl-CoA Reductase InhibitorsLipopolysaccharidesMatrix Metalloproteinase 1Matrix Metalloproteinase 8Matrix Metalloproteinase 9MMP1 protein, humanMMP8 protein, humanMMP9 protein, humanSimvastatindiabetes mellitusmatrix metalloproteinase-1periodontitisstatin

Identifiers

PMID26988924
PMCPMC4899213
OpenAlexW2295019021

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.