ArticleAJNR. American journal of neuroradiology2016
Brain Injury in Neonates with Complex Congenital Heart Disease: What Is the Predictive Value of MRI in the Fetal Period?
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Brain injury in congenital heart disease: pathophysiology, MRI patterns, and perioperative risk factors.Pediatric research · 2026Review
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Research square · 2025Article
- Neuro-Genomic Mapping of Cardiac Neurons with Systemic Analysis Reveals Cognitive and Neurodevelopmental Impacts in Congenital Heart Disease.Life (Basel, Switzerland) · 2025Article
- Validation of a Paralimbic-Related Subcortical Brain Dysmaturation MRI Score in Infants with Congenital Heart Disease.Journal of clinical medicine · 2024Article
- Altered In Utero Metabolic Brain Trajectories in CHD: Going Beyond Fetal Brain Structure and Physiology.Journal of the American College of Cardiology · 2023Article
- Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease.Translational pediatrics · 2023Review
- Risk factors of postoperative neurodevelopmental abnormalities in neonates with critical congenital heart disease.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Article
- Fetal Brain Development in Congenital Heart Disease.The Canadian journal of cardiology · 2023Review
- Regional changes in brain apparent diffusion coefficient in fetuses with complex congenital heart disease and normal pregnancy assessed using diffusion-weighted imaging.Frontiers in neurology · 2023Article
- Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration.Stroke · 2022Article
- Article
- Altered myelination in youth born with congenital heart disease.Human brain mapping · 2022Article
- Altered resting state functional connectivity in youth with congenital heart disease operated during infancy.PloS one · 2022Article
- Reliability of Fetal Echocardiography in Predicting Postnatal Critical Hypoxia in Patients with Transposition of Great Arteries and Intact Ventricular Septum.Pediatric cardiology · 2021Article
- Maternal hyperoxygenation in congenital heart disease.Translational pediatrics · 2021Review
- Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease.Pediatric cardiology · 2021Review
- Brain MRI Radiomics Analysis of School-Aged Children with Tetralogy of Fallot.Computational and mathematical methods in medicine · 2021Article
- The Congenital Heart Disease Brain: Prenatal Considerations for Perioperative Neurocritical Care.Pediatric neurology · 2020Review
- Association of Maternal Psychological Distress With In Utero Brain Development in Fetuses With Congenital Heart Disease.JAMA pediatrics · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
background and purposeBrain injury in neonates with congenital heart disease is an important predictor of adverse neurodevelopmental outcome. Impaired brain development in congenital heart disease may have a prenatal origin, but the sensitivity and specificity of fetal brain MR imaging for predicting neonatal brain lesions are currently unknown. We sought to determine the value of conventional fetal MR imaging for predicting abnormal findings on neonatal preoperative MR imaging in neonates with complex congenital heart disease. MATERIALS AND
methodsMR imaging studies were performed in 103 fetuses with confirmed congenital heart disease (mean gestational age, 31.57 ± 3.86 weeks) and were repeated postnatally before cardiac surgery (mean age, 6.8 ± 12.2 days). Each MR imaging study was read by a pediatric neuroradiologist.
resultsBrain abnormalities were detected in 17/103 (16%) fetuses by fetal MR imaging and in 33/103 (32%) neonates by neonatal MR imaging. Only 9/33 studies with abnormal neonatal findings were preceded by abnormal findings on fetal MR imaging. The sensitivity and specificity of conventional fetal brain MR imaging for predicting neonatal brain abnormalities were 27% and 89%, respectively.
conclusionsBrain abnormalities detected by in utero MR imaging in fetuses with congenital heart disease are associated with higher risk of postnatal preoperative brain injury. However, a substantial proportion of anomalies on postnatal MR imaging were not present on fetal MR imaging; this result is likely due to the limitations of conventional fetal MR imaging and the emergence of new lesions that occurred after the fetal studies. Postnatal brain MR imaging studies are needed to confirm the presence of injury before open heart surgery.
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