ArticleNature communications2016
Cross-modal representations of first-hand and vicarious pain, disgust and fairness in insular and cingulate cortex.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Emotion processing in youths with conduct problems: an fMRI meta-analysis.Translational psychiatry · 2023Pooled it
- Neural signatures of prosocial behaviors.Neuroscience and biobehavioral reviews · 2020Pooled it
- Neural signatures of cooperation enforcement and violation: a coordinate-based meta-analysis.Social cognitive and affective neuroscience · 2019Pooled it
- Brain responses to social norms: Meta-analyses of fMRI studies.Human brain mapping · 2018Pooled it
- Social comparison in the brain: A coordinate-based meta-analysis of functional brain imaging studies on the downward and upward comparisons.Human brain mapping · 2018Pooled it
- Neural signatures of trust in reciprocity: A coordinate-based meta-analysis.Human brain mapping · 2017Pooled it
- Domain-General Neural Effects of Associative Learning and Expectations on Pain and Hedonic Taste Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Trial
- Beyond Sharing Unpleasant Affect-Evidence for Pain-Specific Opioidergic Modulation of Empathy for Pain.Cerebral cortex (New York, N.Y. : 1991) · 2021Trial
- Complementary and opponent value signals in the human brain support choosing the best and avoiding the worst.Nature communications · 2026Article
- Neural representations of dynamical state and trait impulsivity in individuals at risk for internet gaming disorder.Molecular psychiatry · 2026Article
- Towards naturalistic social neuroscience: A multi-level framework integrating real-world phenotyping, neurobiology, and computational mechanisms.Cognitive, affective & behavioral neuroscience · 2026Review
- Neural Mechanisms of Neuroticism: Large-Scale Brain Networks, Developmental Trajectories, and Translational Implications.Brain sciences · 2026Review
- Disgust Propensity, Not Disgust Sensitivity, Shapes the Reactivity of a Subjective Disgust Circuit in Humans.Human brain mapping · 2026Article
- Emotional and Social Dimension of Abstract Concepts Meet with Interoception in Right Anterior Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Age differences in neural discriminability of rumination and worry.Communications biology · 2026Article
- Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Oxytocin and vasopressin enhance social pain empathy via common and distinct of neural expressions, genetic pathways, and networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Quantitative Review of Brain Activation Maps for Mentalizing, Empathy, and Social Interactions: Specifying Commonalities and Differences.Behavioral sciences (Basel, Switzerland) · 2025Review
- Article
- Pain sensitivity mediates the relationship between empathy for pain and psychopathic traits.Scientific reports · 2025Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior insula (AI) and mid-anterior cingulate cortex (mACC) have repeatedly been implicated in first-hand and vicarious experiences of pain, disgust and unfairness. However, it is debated whether these regions process different aversive events through a common modality-independent code, reflecting the shared unpleasantness of the experiences or through independent modality-specific representations. Using functional magnetic resonance imaging, we subjected 19 participants (and 19 confederates) to equally unpleasant painful and disgusting stimulations, as well as unfair monetary treatments. Multivoxel pattern analysis identified modality-independent activation maps in the left AI and mACC, pointing to common coding of affective unpleasantness, but also response patterns specific for the events' sensory properties and the person to whom it was addressed, particularly in the right AI. Our results provide evidence of both functional specialization and integration within AI and mACC, and support a comprehensive role of this network in processing aversive experiences for self and others.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.